Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

by Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
Published 2020-08-01

Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine.

by Alexander B Taylor, Livia Pica-Mattoccia, Chiara M Polcaro, Enrica Donati, Xiaohang Cao, Annalisa Basso, Alessandra Guidi, Anastasia R Rugel, Stephen P Holloway, Timothy J C Anderson, P John Hart, Donato Cioli, Philip T LoVerde
Published 2015-01-01

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

by Meghan A Guzman, Anastasia R Rugel, Reid S Tarpley, Sevan N Alwan, Frédéric D Chevalier, Dmytro P Kovalskyy, Xiaohang Cao, Stephen P Holloway, Timothy J C Anderson, Alexander B Taylor, Stanton F McHardy, Philip T LoVerde
Published 2020-08-01