Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

by Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
Published 2020-08-01

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.

by Meghan A Guzman, Anastasia R Rugel, Reid S Tarpley, Sevan N Alwan, Frédéric D Chevalier, Dmytro P Kovalskyy, Xiaohang Cao, Stephen P Holloway, Timothy J C Anderson, Alexander B Taylor, Stanton F McHardy, Philip T LoVerde
Published 2020-08-01

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

by Frédéric D Chevalier, Winka Le Clec'h, Marina McDew-White, Vinay Menon, Meghan A Guzman, Stephen P Holloway, Xiaohang Cao, Alexander B Taylor, Safari Kinung'hi, Anouk N Gouvras, Bonnie L Webster, Joanne P Webster, Aidan M Emery, David Rollinson, Amadou Garba Djirmay, Khalid M Al Mashikhi, Salem Al Yafae, Mohamed A Idris, Hélène Moné, Gabriel Mouahid, P John Hart, Philip T LoVerde, Timothy J C Anderson
Published 2019-10-01