Understanding the Mechanism of Recognition of Gab2 by the N-SH2 Domain of SHP2

by Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Angelo Toto
Published 2020-06-01

Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2

by Angelo Toto, Francesca Malagrinò, Lorenzo Visconti, Francesca Troilo, Stefano Gianni
Published 2020-01-01

The Effect of Proline <i>cis</i>-<i>trans</i> Isomerization on the Folding of the C-Terminal SH2 Domain from p85

by Francesca Troilo, Francesca Malagrinò, Lorenzo Visconti, Angelo Toto, Stefano Gianni
Published 2019-12-01

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

by Livia Pagano, Angelo Toto, Francesca Malagrinò, Lorenzo Visconti, Per Jemth, Stefano Gianni
Published 2021-01-01

Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls

by Francesca Malagrinò, Lorenzo Visconti, Livia Pagano, Angelo Toto, Francesca Troilo, Stefano Gianni
Published 2020-05-01

Demonstration of Binding Induced Structural Plasticity in a SH2 Domain

by Lorenzo Visconti, Angelo Toto, James A. Jarvis, Francesca Troilo, Francesca Malagrinò, Alfonso De Simone, Stefano Gianni
Published 2020-05-01

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains

by Célia Caillet-Saguy, Angelo Toto, Raphael Guerois, Pierre Maisonneuve, Eva di Silvio, Kristi Sawyer, Stefano Gianni, Nicolas Wolff
Published 2017-08-01

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

by Lorenzo Visconti, Francesca Malagrinò, Luca Broggini, Chiara Maria Giulia De Luca, Fabio Moda, Stefano Gianni, Stefano Ricagno, Angelo Toto
Published 2019-01-01

Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

by Ettore Lo Cascio, Angelo Toto, Gabriele Babini, Flavio De Maio, Maurizio Sanguinetti, Alvaro Mordente, Stefano Della Longa, Alessandro Arcovito
Published 2021-01-01

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

by Francesca Malagrinò, Antonio Coluccia, Marianna Bufano, Giuseppe La Regina, Michela Puxeddu, Angelo Toto, Lorenzo Visconti, Alessio Paone, Maria Chiara Magnifico, Francesca Troilo, Francesca Cutruzzolà, Romano Silvestri, Stefano Gianni
Published 2020-11-01