Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

by Eleonora Porcu, Sina Rüeger, Kaido Lepik, eQTLGen Consortium, BIOS Consortium, Federico A. Santoni, Alexandre Reymond, Zoltán Kutalik
Published 2019-07-01

Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids

by Adriaan van der Graaf, Annique Claringbould, Antoine Rimbert, BIOS Consortium, Harm-Jan Westra, Yang Li, Cisca Wijmenga, Serena Sanna
Published 2020-10-01

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

by Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, BIOS Consortium, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra, Lude Franke
Published 2021-03-01

Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

by Mi Kyeong Lee, Cheng-Jian Xu, Megan U. Carnes, Cody E. Nichols, James M. Ward, The BIOS consortium, Sung Ok Kwon, Sun-Young Kim, Woo Jin Kim, Stephanie J. London
Published 2019-02-01

DNA methylation is associated with lung function in never smokers

by Maaike de Vries, Ivana Nedeljkovic, Diana A. van der Plaat, Alexandra Zhernakova, Lies Lahousse, Guy G. Brusselle, BIOS Consortium, Najaf Amin, Cornelia M. van Duijn, Judith M. Vonk, H. Marike Boezen
Published 2019-12-01

Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

by Jeroen van Rooij, Pooja R. Mandaviya, Annique Claringbould, Janine F. Felix, Jenny van Dongen, Rick Jansen, Lude Franke, BIOS consortium, Peter A. C. ’t Hoen, Bas Heijmans, Joyce B. J. van Meurs
Published 2019-11-01

Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification

by Xiaoling Zhang, Jeroen G. J. van Rooij, Yoshiyuki Wakabayashi, Shih-Jen Hwang, Yanqin Yang, Mohsen Ghanbari, Daniel Bos, BIOS Consortium, Daniel Levy, Andrew D. Johnson, Joyce B. J. van Meurs, Maryam Kavousi, Jun Zhu, Christopher J. O’Donnell
Published 2021-02-01

RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting

by Bharati Jadhav, Ramin Monajemi, Kristina K. Gagalova, Daniel Ho, Harmen H. M. Draisma, Mark A. van de Wiel, Lude Franke, Bastiaan T. Heijmans, Joyce van Meurs, Rick Jansen, GoNL Consortium, BIOS Consortium, Peter A. C. ‘t Hoen, Andrew J. Sharp, Szymon M. Kiełbasa
Published 2019-06-01

A SNP panel for identification of DNA and RNA specimens

by Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van ‘t Hof, Maarten van Iterson, Daria V. Zhernakova, Annique Claringbould, Lude Franke, Leen M. ‘t Hart, Roderick C. Slieker, Amber van der Heijden, Peter de Knijff, BIOS consortium, Peter A. C. ’t Hoen
Published 2018-01-01

Genetic and environmental influences interact with age and sex in shaping the human methylome

by Jenny van Dongen, Michel G. Nivard, Gonneke Willemsen, Jouke-Jan Hottenga, Quinta Helmer, Conor V. Dolan, Erik A. Ehli, Gareth E. Davies, Maarten van Iterson, Charles E. Breeze, Stephan Beck, BIOS Consortium, H. Eka Suchiman, Rick Jansen, Joyce B. van Meurs, Bastiaan T. Heijmans, P. Eline Slagboom, Dorret I. Boomsma
Published 2016-04-01

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

by Paul J. Hop, René Luijk, Lucia Daxinger, Maarten van Iterson, Koen F. Dekkers, Rick Jansen, BIOS Consortium, Joyce B. J. van Meurs, Peter A. C. ’t Hoen, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Dorret I. Boomsma, P. Eline Slagboom, Jan H. Veldink, Erik W. van Zwet, Bastiaan T. Heijmans
Published 2020-08-01

Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

by Adriaan van der Graaf, Maria M. Zorro, Annique Claringbould, Urmo Võsa, Urmo Võsa, Raúl Aguirre-Gamboa, Chan Li, Chan Li, Joram Mooiweer, Isis Ricaño-Ponce, Zuzanna Borek, Zuzanna Borek, Frits Koning, Yvonne Kooy-Winkelaar, Ludvig M. Sollid, Shuo-Wang Qiao, Vinod Kumar, Vinod Kumar, Yang Li, Yang Li, Yang Li, Lude Franke, Sebo Withoff, Cisca Wijmenga, Cisca Wijmenga, Serena Sanna, Serena Sanna, Iris Jonkers, Iris Jonkers, BIOS Consortium
Published 2021-01-01

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

by Raúl Aguirre-Gamboa, Niek de Klein, Jennifer di Tommaso, Annique Claringbould, Monique GP van der Wijst, Dylan de Vries, Harm Brugge, Roy Oelen, Urmo Võsa, Maria M. Zorro, Xiaojin Chu, Olivier B. Bakker, Zuzanna Borek, Isis Ricaño-Ponce, Patrick Deelen, Cheng-Jiang Xu, Morris Swertz, Iris Jonkers, Sebo Withoff, Irma Joosten, Serena Sanna, Vinod Kumar, Hans J. P. M. Koenen, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, BIOS Consortium, Lude Franke, Yang Li
Published 2020-06-01

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

by René Luijk, Haoyu Wu, Cavin K Ward-Caviness, Eilis Hannon, Elena Carnero-Montoro, Josine L. Min, Pooja Mandaviya, Martina Müller-Nurasyid, Hailiang Mei, Silvere M. van der Maarel, BIOS Consortium, Caroline Relton, Jonathan Mill, Melanie Waldenberger, Jordana T. Bell, Rick Jansen, Alexandra Zhernakova, Lude Franke, Peter A. C. ‘t Hoen, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Joyce van Meurs, Lucia Daxinger, P. Eline Slagboom, Erik W. van Zwet, Bastiaan T. Heijmans
Published 2018-09-01

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes.

by Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemans, Chunyu Liu, Allan F McRae, Michael M Mendelson, Martina Müller-Nurasyid, Annette Peters, P Eline Slagboom, John M Starr, David-Alexandre Trégouët, André G Uitterlinden, Marleen M J van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S Wells, Chen Yao, Ian J Deary, France Gagnon, Bastiaan T Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G Heil, Joyce B J van Meurs, CHARGE Consortium Epigenetics group and BIOS Consortium
Published 2017-01-01

Identical twins carry a persistent epigenetic signature of early genome programming

by Jenny van Dongen, Scott D. Gordon, Allan F. McRae, Veronika V. Odintsova, Hamdi Mbarek, Charles E. Breeze, Karen Sugden, Sara Lundgren, Juan E. Castillo-Fernandez, Eilis Hannon, Terrie E. Moffitt, Fiona A. Hagenbeek, Catharina E. M. van Beijsterveldt, Jouke Jan Hottenga, Pei-Chien Tsai, BIOS Consortium, Genetics of DNA Methylation Consortium, Josine L. Min, Gibran Hemani, Erik A. Ehli, Franziska Paul, Claudio D. Stern, Bastiaan T. Heijmans, P. Eline Slagboom, Lucia Daxinger, Silvère M. van der Maarel, Eco J. C. de Geus, Gonneke Willemsen, Grant W. Montgomery, Bruno Reversade, Miina Ollikainen, Jaakko Kaprio, Tim D. Spector, Jordana T. Bell, Jonathan Mill, Avshalom Caspi, Nicholas G. Martin, Dorret I. Boomsma
Published 2021-09-01