Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook

by Lena Horvath, Bernard Thienpont, Liyun Zhao, Dominik Wolf, Andreas Pircher
Published 2020-09-01

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

by Steve Stegen, Ingrid Stockmans, Karen Moermans, Bernard Thienpont, Patrick H. Maxwell, Peter Carmeliet, Geert Carmeliet
Published 2018-07-01

Network analysis of differential expression for the identification of disease-causing genes.

by Daniela Nitsch, Léon-Charles Tranchevent, Bernard Thienpont, Lieven Thorrez, Hilde Van Esch, Koenraad Devriendt, Yves Moreau
Published 2009-01-01

A new protocol for single-cell RNA-seq reveals stochastic gene expression during lag phase in budding yeast

by Abbas Jariani, Lieselotte Vermeersch, Bram Cerulus, Gemma Perez-Samper, Karin Voordeckers, Thomas Van Brussel, Bernard Thienpont, Diether Lambrechts, Kevin J Verstrepen
Published 2020-05-01

Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming

by Michela Bartoccetti, Bernard K. van der Veer, Xinlong Luo, Rita Khoueiry, Pinyi She, Manmohan Bajaj, Jiayi Xu, Adrian Janiszewski, Bernard Thienpont, Vincent Pasque, Kian Peng Koh
Published 2020-03-01

Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming

by Michela Bartoccetti, Bernard K. van der Veer, Xinlong Luo, Rita Khoueiry, Pinyi She, Manmohan Bajaj, Jiayi Xu, Adrian Janiszewski, Bernard Thienpont, Vincent Pasque, Kian Peng Koh
Published 2020-02-01

Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

by Hui Zhao, Bernard Thienpont, Betül Tuba Yesilyurt, Matthieu Moisse, Joke Reumers, Lieve Coenegrachts, Xavier Sagaert, Stefanie Schrauwen, Dominiek Smeets, Gert Matthijs, Stein Aerts, Jan Cools, Alex Metcalf, Amanda Spurdle, ANECS, Frederic Amant, Diether Lambrechts
Published 2014-08-01

Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease

by Jose M. G. Izarzugaza, Sabrina G. Ellesøe, Canan Doganli, Natasja Spring Ehlers, Marlene D. Dalgaard, Enrique Audain, Gregor Dombrowsky, Karina Banasik, Alejandro Sifrim, Anna Wilsdon, Bernard Thienpont, Jeroen Breckpot, Marc Gewillig, Competence Network for Congenital Heart Defects, Germany, J. David Brook, Marc-Phillip Hitz, Lars A. Larsen, Søren Brunak
Published 2020-08-01

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

by Anna Kuchnio, Stijn Moens, Ulrike Bruning, Karol Kuchnio, Bert Cruys, Bernard Thienpont, Michaël Broux, Andreea Alexandra Ungureanu, Rodrigo Leite de Oliveira, Françoise Bruyère, Henar Cuervo, Ann Manderveld, An Carton, Juan Ramon Hernandez-Fernaud, Sara Zanivan, Carmen Bartic, Jean-Michel Foidart, Agnes Noel, Stefan Vinckier, Diether Lambrechts, Mieke Dewerchin, Massimiliano Mazzone, Peter Carmeliet
Published 2015-08-01

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

by Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Published 2020-07-01

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.

by Enrique Audain, Anna Wilsdon, Jeroen Breckpot, Jose M G Izarzugaza, Tomas W Fitzgerald, Anne-Karin Kahlert, Alejandro Sifrim, Florian Wünnemann, Yasset Perez-Riverol, Hashim Abdul-Khaliq, Mads Bak, Anne S Bassett, Woodrow D Benson, Felix Berger, Ingo Daehnert, Koenraad Devriendt, Sven Dittrich, Piers Ef Daubeney, Vidu Garg, Karl Hackmann, Kirstin Hoff, Philipp Hofmann, Gregor Dombrowsky, Thomas Pickardt, Ulrike Bauer, Bernard D Keavney, Sabine Klaassen, Hans-Heiner Kramer, Christian R Marshall, Dianna M Milewicz, Scott Lemaire, Joseph S Coselli, Michael E Mitchell, Aoy Tomita-Mitchell, Siddharth K Prakash, Karl Stamm, Alexandre F R Stewart, Candice K Silversides, Reiner Siebert, Brigitte Stiller, Jill A Rosenfeld, Inga Vater, Alex V Postma, Almuth Caliebe, J David Brook, Gregor Andelfinger, Matthew E Hurles, Bernard Thienpont, Lars Allan Larsen, Marc-Phillip Hitz
Published 2021-07-01