Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

by Soumya R. Mohapatra, Ahmed Sadik, Ahmed Sadik, Lars-Oliver Tykocinski, Jørn Dietze, Gernot Poschet, Ines Heiland, Christiane A. Opitz, Christiane A. Opitz
Published 2019-12-01

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy

by Philipp Zimmer, Philipp Zimmer, Martina E. Schmidt, Mirja Tamara Prentzell, Bianca Berdel, Joachim Wiskemann, Karl Heinz Kellner, Jürgen Debus, Cornelia Ulrich, Christiane A. Opitz, Christiane A. Opitz, Karen Steindorf
Published 2019-09-01

The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells.

by Christiane A Opitz, Ulrike M Litzenburger, Uta Opitz, Felix Sahm, Katharina Ochs, Christian Lutz, Wolfgang Wick, Michael Platten
Published 2011-01-01

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production

by Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Tobias V. Lanz, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmüller, Ursula Klingmüller, Michael Platten, Michael Platten, Ines Heiland, Christiane A. Opitz, Christiane A. Opitz
Published 2021-02-01

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

by Takumi Kudo, Takumi Kudo, Takumi Kudo, Mirja T. Prentzell, Soumya R. Mohapatra, Felix Sahm, Felix Sahm, Zhongliang Zhao, Ingrid Grummt, Wolfgang Wick, Wolfgang Wick, Christiane A. Opitz, Christiane A. Opitz, Michael Platten, Michael Platten, Edward W. Green, Edward W. Green
Published 2020-05-01

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.

by Alexander Lercher, Alexandra M Popa, Csilla Viczenczova, Lindsay Kosack, Kristaps Klavins, Benedikt Agerer, Christiane A Opitz, Tobias V Lanz, Michael Platten, Andreas Bergthaler
Published 2020-10-01

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

by Isabell Adam, Dyah L. Dewi, Joram Mooiweer, Ahmed Sadik, Soumya R. Mohapatra, Bianca Berdel, Melanie Keil, Jana K. Sonner, Kathrin Thedieck, Adam J. Rose, Michael Platten, Ines Heiland, Saskia Trump, Christiane A. Opitz
Published 2018-12-01

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer

by Dyah L. Dewi, Soumya R. Mohapatra, Saioa Blanco Cabañes, Isabell Adam, Luis F. Somarribas Patterson, Bianca Berdel, Masroor Kahloon, Loreen Thürmann, Stefanie Loth, Katharina Heilmann, Dieter Weichenhan, Oliver Mücke, Ines Heiland, Pauline Wimberger, Jan Dominik Kuhlmann, Karl-Heinz Kellner, Sarah Schott, Christoph Plass, Michael Platten, Clarissa Gerhäuser, Saskia Trump, Christiane A. Opitz
Published 2017-02-01

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

by Jana K. Sonner, Melanie Keil, Maren Falk-Paulsen, Neha Mishra, Ateequr Rehman, Magdalena Kramer, Katrin Deumelandt, Julian Röwe, Khwab Sanghvi, Lara Wolf, Anna von Landenberg, Hendrik Wolff, Richa Bharti, Iris Oezen, Tobias V. Lanz, Florian Wanke, Yilang Tang, Ines Brandao, Soumya R. Mohapatra, Lisa Epping, Alexandra Grill, Ralph Röth, Beate Niesler, Sven G. Meuth, Christiane A. Opitz, Jürgen G. Okun, Christoph Reinhardt, Florian C. Kurschus, Wolfgang Wick, Helge B. Bode, Philip Rosenstiel, Michael Platten
Published 2019-10-01