Endospores and other lysis-resistant bacteria comprise a widely shared core community within the human microbiota

by Bullock, Kevin, Allegretti, Jessica R., Clish, Clary B., Kearney, Sean M, Gibbons, Sean Michael, Poyet, Mathilde, Gurry, Thomas Jerome, Alm, Eric J
Published 2018

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

by Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C, Jeanson, Nathaniel T, Clish, Clary B, Cantley, Lewis C, Scadden, David T, Israelsen, William James, Vander Heiden, Matthew G.
Published 2016

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

by Dunn, Denise E., Avila-Pacheco, Julian, Greengard, Paul, Clish, Clary B., Lo, Donald C., Pirhaji, Leila, Milani, Pamela, Dalin, Simona, Wassie, Brook T., Fenster, Robert, Heiman, Myriam, Fraenkel, Ernest
Published 2017

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

by Clish, Clary B., Bronson, Roderick T., Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn, Israelsen, William James, Bhutkar, Arjun, Davidson, Shawn Michael, Luengo, Alba, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

by Tang, Yun-Chi, Yuwen, Hui, Wang, Kaiying, Bruno, Peter M., Bullock, Kevin, Deik, Amy, Zhong, Na, Huang, Tao, Wang, Lan, Clish, Clary B., Hemann, Michael T., Santaguida, Stefano, Trakala, Marianna, Pfau, Sarah Jeanne, Amon, Angelika B
Published 2018

A Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up Study

by Dickerman, Barbra A., Ebot, Ericka M., Healy, Brian C., Wilson, Kathryn M., Eliassen, A. Heather, Ascherio, Alberto, Pernar, Claire H., Zeleznik, Oana A., Vander Heiden, Matthew G., Clish, Clary B., Giovannucci, Edward, Mucci, Lorelei A.
Published 2020

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

by Bao, Xiaoyan Robert, Ong, Shao-En, Goldberger, Olga, Peng, Jun, Sharma, Rohit, Thompson, Dawn A, Vafai, Scott B, Cox, Andrew G, Marutani, Eizo, Ichinose, Fumito, Goessling, Wolfram, Carr, Steven A, Clish, Clary B, Mootha, Vamsi K, Regev, Aviv
Published 2016

Association of Prediagnostic Blood Metabolomics with Prostate Cancer Defined by ERG or PTEN Molecular Subtypes

by Feng, Xiaoshuang, Zhou, Cindy Ke, Clish, Clary B, Wilson, Kathryn M, Pernar, Claire H, Dickerman, Barbra A, Loda, Massimo, Finn, Stephen P, Penney, Kathryn L, Schmidt, Daniel R, Heiden, Matthew G Vander, Giovannucci, Edward L, Ebot, Ericka M, Mucci, Lorelei A
Published 2021

Association of Prediagnostic Blood Metabolomics with Prostate Cancer Defined by ERG or PTEN Molecular Subtypes

by Feng, Xiaoshuang, Zhou, Cindy Ke, Clish, Clary B., Wilson, Kathryn M., Pernar, Claire H., Dickerman, Barbra A., Loda, Massimo, Finn, Stephen P., Penney, Kathryn L., Schmidt, Daniel R., Heiden, Matthew G. Vander, Giovannucci, Edward L., Ebot, Ericka M., Mucci, Lorelei A.
Published 2022

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

by Olenchock, Benjamin A, Moslehi, Javid, Baik, Alan H, Williams, Jeremy, Gibson, William J, Chakraborty, Abhishek A, Pierce, Kerry A, Miller, Christine M, Hanse, Eric A, Kelekar, Ameeta, Wagers, Amy J, Clish, Clary B, Kaelin, William G, Davidson, Shawn M, Sullivan, Lucas Bryan, Vander Heiden, Matthew G.
Published 2017

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

by Wang, Chao, Yosef, Nir, Gaublomme, Jellert, Wu, Chuan, Lee, Youjin, Clish, Clary B, Kaminski, Jim, Xiao, Sheng, Zu Horste, Gerd Meyer, Pawlak, Mathias, Kishi, Yasuhiro, Joller, Nicole, Karwacz, Katarzyna, Zhu, Chen, Ordovas-Montanes, Maria, Madi, Asaf, Wortman, Ivo, Miyazaki, Toru, Sobel, Raymond A, Park, Hongkun, Regev, Aviv, Kuchroo, Vijay K
Published 2016

Targeting MTHFD2 in acute myeloid leukemia

by Pikman, Yana, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Banerji, Versha, Stegmaier, Kimberly, Puissant, Alexandre, Lewis, Caroline, Ramos, Azucena, Hemann, Michael, Vander Heiden, Matthew G.
Published 2017

Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features

by Madison, Jon M, Duong, Karen, Vieux, Ellen F, Udeshi, Namrata D, Iqbal, Sumaiya, Requadt, Elise, Fereshetian, Shaunt, Lewis, Michael C, Gomes, Antonio S, Pierce, Kerry A, Platt, Randall J, Zhang, Feng, Campbell, Arthur J, Lal, Dennis, Wagner, Florence F, Clish, Clary B, Carr, Steven A, Sheng, Morgan, Scolnick, Edward M, Cottrell, Jeffrey R
Published 2021

Targeting MTHFD2 in acute myeloid leukemia

by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline, Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael, Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly
Published 2022

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

by Papagiannakopoulos, Thales, Olenchock, Benjamin A, Heyman, Julia E, Jha, Abhishek K, Pierce, Kerry A, Mott, Bryan T, Clish, Clary B, Davidson, Shawn M., Luengo, Alba, Bauer, Matthew R., Keibler, Mark Andrew, O'Brien, James P., Gui, Dan Yi, Sullivan, Lucas Bryan, Wasylenko, Thomas Michael, Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2018

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

by Li, Jie, Sasaki, Mika, Horner, James W, Burga, Laura N, Xie, Jianxin, Jurczak, Michael J, DePinho, Ronald A, Clish, Clary B, Kibbey, Richard G, Wulf, Gerburg M, Di Vizio, Dolores, Mills, Gordon B, Cantley, Lewis C, Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2017

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

by Babic, Ana, Rosenthal, Michael H., Bamlet, William R., Takahashi, Naoki, Sugimoto, Motokazu, Danai, Laura V., Morales-Oyarvide, Vicente, Khalaf, Natalia, Dunne, Richard F., Brais, Lauren K., Welch, Marisa W., Zellers, Caitlin L., Dennis, Courtney, Rifai, Nader, Prado, Carla M., Caan, Bette, Sundaresan, Tilak K., Meyerhardt, Jeffrey A., Kulke, Matthew H., Clish, Clary B., Ng, Kimmie, Vander Heiden, Matthew G., Petersen, Gloria M., Wolpin, Brian M.
Published 2020

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

by Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran, Ho, Gary P.H, Noble, Tallie, Sandoe, Jackson, Lou, Yali, Landgraf, Dirk, Freyzon, Yelena, Newby, Gregory, Soldner, Frank, Terry-Kantor, Elizabeth, Kim, Tae-Eun, Hofbauer, Harald F., Becuwe, Michel, Jaenisch, Rudolf, Pincus, David, Clish, Clary B., Walther, Tobias C., Farese, Robert V., Srinivasan, Supriya, Welte, Michael A., Kohlwein, Sepp D., Dettmer, Ulf, Lindquist, Susan, Selkoe, Dennis
Published 2020

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

by Rusu, Victor, Hoch, Eitan, Mercader, Josep M., Tenen, Danielle E., Gymrek, Melissa, Hartigan, Christina R., DeRan, Michael, von Grotthuss, Marcin, Fontanillas, Pierre, Spooner, Alexandra, Guzman, Gaelen, Deik, Amy A., Pierce, Kerry A., Dennis, Courtney, Clish, Clary B., Carr, Steven A., Wagner, Bridget K., Schenone, Monica, Ng, Maggie C.Y, Chen, Brian H., Centeno-Cruz, Federico, Zerrweck, Carlos, Orozco, Lorena, Schreiber, Stuart L., Florez, Jose C., Jacobs, Suzanne B.R, Ng, Maggie C.Y, Shriner, Daniel, Chen, Brian H., Li, Jiang, Chen, Wei-Min, Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J., Yanek, Lisa R., Nalls, Michael A., Comeau, Mary E., Rasmussen-Torvik, Laura J., Jensen, Richard A., Evans, Daniel S., Sun, Yan V., An, Ping, Patel, Sanjay R., Lu, Yingchang, Long, Jirong, Armstrong, Loren L., Wagenknecht, Lynne, Yang, Lingyao, Snively, Beverly M., Palmer, Nicholette D., Mudgal, Poorva, Langefeld, Carl D., Keene, Keith L., Freedman, Barry I., Mychaleckyj, Josyf C., Nayak, Uma, Raffel, Leslie J., Goodarzi, Mark O., Chen, Y-D Ida, Taylor, Herman A., Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S., Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Chen, Guanjie, Mathias, Rasika A., Vaidya, Dhananjay, Singleton, Andrew B., Zonderman, Alan B., Igo, Robert P., Sedor, John R., Kabagambe, Edmond K., Siscovick, David S., McKnight, Barbara, Rice, Kenneth, Liu, Yongmei, Hsueh, Wen-Chi, Zhao, Wei, Bielak, Lawrence F., Kraja, Aldi, Province, Michael A., Bottinger, Erwin P., Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J., Lowe, William L., Pacheco, Jennifer A., Crawford, Dana C., Grundberg, Elin, Rich, Stephen S., Hayes, M. Geoffrey, Shu, Xiao-Ou, Loos, Ruth J.F, Borecki, Ingrid B., Peyser, Patricia A., Cummings, Steven R., Psaty, Bruce M., Fornage, Myriam, Iyengar, Sudha K., Evans, Michele K., Becker, Diane M., Kao, W.H. Linda, Wilson, James G., Rotter, Jerome I., Sale, Michèle M., Liu, Simin, Rotimi, Charles N., Bowden, Donald W., Mercader, Josep M., Huerta-Chagoya, Alicia, García-Ortiz, Humberto, Moreno-Macías, Hortensia, Manning, Alisa, Caulkins, Lizz, Burtt, Noël P., Flannick, Jason, Patterson, Nick, Aguilar-Salinas, Carlos A., Tusié-Luna, Teresa, Altshuler, David, Florez, Jose C., Martínez-Hernández, Angélica, Centeno-Cruz, Federico, Barajas-Olmos, Francisco Martin, Zerrweck, Carlos, Contreras-Cubas, Cecilia, Mendoza-Caamal, Elvia, Revilla-Monsalve, Cristina, Islas-Andrade, Sergio, Córdova, Emilio, Soberón, Xavier, Orozco, Lorena, González-Villalpando, Clicerio, González-Villalpando, María Elena, Haiman, Christopher A., Wilkens, Lynne, Le Marchand, Loic, Monroe, Kristine, Kolonel, Laurence, Arellano-Campos, Olimpia, Ordóñez-Sánchez, Maria L., Rodríguez-Torres, Maribel, Segura-Kato, Yayoi, Rodríguez-Guillén, Rosario, Cruz-Bautista, Ivette, Muñoz-Hernandez, Linda Liliana, Sáenz, Tamara, Gómez, Donají, Alvirde, Ulices, Almeda-Valdés, Paloma, Cortes, Maria L., Lander, Eric Steven, Altshuler, David
Published 2018