Toxin-Based Targeted Therapy for Malignant Brain Tumors

by Vidyalakshmi Chandramohan, John H. Sampson, Ira Pastan, Darell D. Bigner
Published 2012-01-01

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.

by Matthew Wortham, Genglin Jin, Julia Lailai Sun, Darell D Bigner, Yiping He, Hai Yan
Published 2012-01-01

Monitoring Radiographic Brain Tumor Progression

by John H. Sampson, Darell D. Bigner, Allan H. Friedman, Charles W. Kanaly, Ankit I. Mehta
Published 2011-03-01

Glioblastoma Multiforme Oncogenomics and Signaling Pathways

by Okezie O. Kanu, Betsy Hughes, Chunhui Di, Ningjing Lin, Jinrong Fu, Darell D. Bigner, Hai Yan, Cory Adamson
Published 2009-01-01

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

by Xin Yu, Mikhail Dobrikov, Stephen T Keir, Matthias Gromeier, Ira H Pastan, Ralph Reisfeld, Darell D Bigner, Vidyalakshmi Chandramohan
Published 2019-01-01

Immunotoxin Therapy for Lung Cancer

by Li-Yi Xie, Hai-Lan Piao, Min Fan, Zhen Zhang, Chen Wang, Darell D Bigner, Xu-Hui Bao
Published 2017-01-01

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.

by Genglin Jin, Zachary J Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D Bigner, Hai Yan
Published 2011-02-01

Imaging of Convection Enhanced Delivery of Toxins in Humans

by Allan H. Friedman, Darell D. Bigner, John H. Sampson, Ira Pastan, Martin Brady, Raghu Raghavan, Bryan D. Choi, Ankit I. Mehta
Published 2011-03-01

Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

by Mubeen M. Mosaheb, Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, Matthias Gromeier
Published 2020-01-01

A novel method for volumetric MRI response assessment of enhancing brain tumors.

by Charles W Kanaly, Dale Ding, Ankit I Mehta, Anthony F Waller, Ian Crocker, Annick Desjardins, David A Reardon, Allan H Friedman, Darell D Bigner, John H Sampson
Published 2011-01-01

Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma

by Matthias Gromeier, Darell D Bigner, Smita K Nair, Karenia Landa, Sin-Ho Jung, Georgia M Beasley, Norma E Farrow, Maria Angelica Selim, Carol Ann Wiggs, Andrea True Kelly, April KS Salama
Published 2021-04-01

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

by Vidyalakshmi Chandramohan, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, Annick Desjardins, Michael D. Gunn, Matthias Gromeier, Smita K. Nair, Ira H. Pastan, Darell D. Bigner
Published 2019-05-01

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

by Luis A Sanchez-Perez, Bryan D Choi, Gary E Archer, Xiuyu Cui, Catherine Flores, Laura A Johnson, Robert J Schmittling, David Snyder, James E Herndon, Darell D Bigner, Duane A Mitchell, John H Sampson
Published 2013-01-01

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling

by Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Published 2021-03-01

Application of mutagen sensitivity assay in a glioma case-control study

by Serap Erdal, Bridget J. McCarthy, Natalia Gurule, Marianne Berwick, Emily Gonzales, Johanna Byrd, Kristina Flores, JoAnna Shimek, Dora Il’yasova, Francis Ali-Osman, Darell D. Bigner, Faith G. Davis, Alexis N. Leyba, Kirsten A.M. White
Published 2018-01-01

EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.

by Hongsheng Miao, Bryan D Choi, Carter M Suryadevara, Luis Sanchez-Perez, Shicheng Yang, Gabriel De Leon, Elias J Sayour, Roger McLendon, James E Herndon, Patrick Healy, Gary E Archer, Darell D Bigner, Laura A Johnson, John H Sampson
Published 2014-01-01

Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.

by Laura M Epple, Rebecca D Dodd, Andrea L Merz, Anjelika M Dechkovskaia, Matthew Herring, Benjamin A Winston, Alex M Lencioni, Rae L Russell, Helen Madsen, Meheret Nega, Nathaniel L Dusto, Jason White, Darell D Bigner, Christopher V Nicchitta, Natalie J Serkova, Michael W Graner
Published 2013-01-01

A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.

by John H Sampson, Robert J Schmittling, Gary E Archer, Kendra L Congdon, Smita K Nair, Elizabeth A Reap, Annick Desjardins, Allan H Friedman, Henry S Friedman, James E Herndon, April Coan, Roger E McLendon, David A Reardon, James J Vredenburgh, Darell D Bigner, Duane A Mitchell
Published 2012-01-01

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

by Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Published 2018-05-01

Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy

by Matthias Gromeier, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E. Herndon, Frederick S. Varn, Roel G. Verhaak, Junfei Zhao, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, Frances McSherry, Andrea M. Muscat, Eric S. Lipp, Smita K. Nair, Mustafa Khasraw, Katherine B. Peters, Dina Randazzo, John H. Sampson, Roger E. McLendon, Darell D. Bigner, David M. Ashley
Published 2021-01-01