Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.

by William T Festuccia, Philippe Pouliot, Inan Bakan, David M Sabatini, Mathieu Laplante
Published 2014-01-01

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

by Lawrence D. Schweitzer, William C. Comb, Liron Bar-Peled, David M. Sabatini
Published 2015-09-01

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

by Lan eYe, Behzad eVaramini, Dudley W. Lamming, David M. Sabatini, Joseph A. Baur
Published 2012-09-01

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells

by G. Jordan Ray, Elizabeth A. Boydston, Emily Shortt, Gregory A. Wyant, Sebastian Lourido, Walter W. Chen, David M. Sabatini
Published 2020-05-01

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

by Alexandre Caron, Sébastien M. Labbé, Damien Lanfray, Pierre-Gilles Blanchard, Romain Villot, Christian Roy, David M. Sabatini, Denis Richard, Mathieu Laplante
Published 2016-02-01

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility

by Christopher J. Yuskaitis, Brandon M. Jones, Rachel L. Wolfson, Chloe E. Super, Sameer C. Dhamne, Alexander Rotenberg, David M. Sabatini, Mustafa Sahin, Annapurna Poduri
Published 2018-03-01

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
Published 2014-10-01

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

by Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea
Published 2018-05-01

Loss of hepatic DEPTOR alters the metabolic transition to fasting

by Alexandre Caron, Mathilde Mouchiroud, Nicolas Gautier, Sébastien M. Labbé, Romain Villot, Laurie Turcotte, Blandine Secco, Guillaume Lamoureux, Michael Shum, Yves Gélinas, André Marette, Denis Richard, David M. Sabatini, Mathieu Laplante
Published 2017-05-01

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

by Walter W. Chen, Kıvanç Birsoy, Maria M. Mihaylova, Harriet Snitkin, Iwona Stasinski, Burcu Yucel, Erol C. Bayraktar, Jan E. Carette, Clary B. Clish, Thijn R. Brummelkamp, David D. Sabatini, David M. Sabatini
Published 2014-04-01

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

by Nadia Rasheed, Tatiani B. Lima, Gustavo F. Mercaldi, Andrey F.Z. Nascimento, Ana L.S. Silva, Germanna L. Righetto, Liron Bar‐Peled, Kuang Shen, David M. Sabatini, Fabio C. Gozzo, Ricardo Aparicio, Juliana H.C. Smetana
Published 2019-09-01

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

by Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan
Published 2021-06-01

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

by Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat, Omer H. Yilmaz, Maya Mitalipova, Kevin Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard A. Fine, Anne E. Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard A. Young, Keith L. Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William C. Hahn, Milan G. Chheda
Published 2014-01-01

Lysosomal nutrients and the mTORC1 pathway

by Wyant, Gregory A.(Gregory Andrew)
Published 2019

Discovering regulators of the amino acid sensing pathway of mTORC1

by Chantranupong, Lynne
Published 2017

Regulation of the mTORC1 growth pathway by amino acids

by Tsun, Zhi-Yang
Published 2015

Pathological features of mitochondrial respiratory chain dysfunction

by Chen, Walter W
Published 2016

Studies of amino acid sensing by the mTORC 1 pathway

by Wang, Shuyu, Ph. D. Massachusetts Institute of Technology
Published 2017

Amino acid regulation of mTORC1

by Bar-Peled, Liron
Published 2014

A multi-level approach to understanding the regulation of translation initiation

by Keys, Heather R. (Heather Rochelle)
Published 2017