Intracellular PD Modelling (<i>PD</i>_i) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

by Ghaith Aljayyoussi, Samantha Donnellan, Stephen A. Ward, Giancarlo A. Biagini
Published 2019-06-01

Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress.

by Donelly A van Schalkwyk, Kevin J Saliba, Giancarlo A Biagini, Patrick G Bray, Kiaran Kirk
Published 2013-01-01

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

by Ghaith Aljayyoussi, Victoria A. Jenkins, Raman Sharma, Alison Ardrey, Samantha Donnellan, Stephen A. Ward, Giancarlo A. Biagini
Published 2017-03-01

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infecti...

by Celina Jin, Malick M Gibani, Shaun H Pennington, Xinxue Liu, Alison Ardrey, Ghaith Aljayyoussi, Maria Moore, Brian Angus, Christopher M Parry, Giancarlo A Biagini, Nicholas A Feasey, Andrew J Pollard
Published 2019-12-01

Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falci...

by Daniel G Wootton, Hyginus Opara, Giancarlo A Biagini, Maxwell K Kanjala, Stephan Duparc, Paula L Kirby, Mary Woessner, Colin Neate, Maggie Nyirenda, Hannah Blencowe, Queen Dube-Mbeye, Thomas Kanyok, Stephen Ward, Malcolm Molyneux, Sam Dunyo, Peter A Winstanley
Published 2008-03-01

Antimalarial activity of primaquine operates via a two-step biochemical relay

by Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Published 2019-07-01

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites

by Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod, Rima McLeod
Published 2020-06-01

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

by Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Published 2017-05-01