Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

by Judith Straimer, Nina F. Gnadig, Barbara H. Stokes, Michelle Ehrenberger, Audrey A. Crane, David A. Fidock, Louis H. Miller
Published 2017-04-01

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

by M. Isabel Veiga, Satish K. Dhingra, Philipp P. Henrich, Judith Straimer, Nina Gnädig, Anne-Catrin Uhlemann, Rowena E. Martin, Adele M. Lehane, David A. Fidock
Published 2016-05-01

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.

by Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Published 2020-04-01

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

by Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Published 2015-04-01

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

by Kyle Jarrod McLean, Judith Straimer, Christine S. Hopp, Joel Vega-Rodriguez, Jennifer L. Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C. Dumoulin, Chantal T. Harris, Xinran Tong, Melanie J. Shears, Johan Ankarklev, Björn F. C. Kafsack, David A. Fidock, Photini Sinnis
Published 2019-09-01

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

by Barbara H Stokes, Satish K Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F Gnädig, Ioanna Deni, Kyra A Schindler, Jade R Bath, Kurt E Ward, Josefine Striepen, Tomas Yeo, Leila S Ross, Eric Legrand, Frédéric Ariey, Clark H Cunningham, Issa M Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M Kabanywanyi, Aline Uwimana, Samuel J Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, François Nosten, Timothy JC Anderson, Philip J Rosenthal, Didier Ménard, David A Fidock
Published 2021-07-01

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

by Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Published 2016-10-01

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

by Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Published 2017-05-01