Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells.

by John Gatfield, Celia Mueller Grandjean, Thomas Sasse, Martine Clozel, Oliver Nayler
Published 2012-01-01

Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator.

by Markus Rey, Patrick Hess, Martine Clozel, Stéphane Delahaye, John Gatfield, Oliver Nayler, Beat Steiner
Published 2013-01-01

Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes.

by Sylvaine You, Luca Piali, Chantal Kuhn, Beat Steiner, Virginia Sauvaget, Fabrice Valette, Martine Clozel, Jean-François Bach, Lucienne Chatenoud
Published 2013-01-01

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

by Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Ric N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Published 2016-10-01