Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions

by Rafael Aldabe, Lester Suárez-Amarán, Carla Usai, Gloria González-Aseguinolaza
Published 2015-02-01

Novel vectors and approaches for gene therapy in liver diseasesKey points

by Sheila Maestro, Nicholas D. Weber, Nerea Zabaleta, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza
Published 2021-08-01

Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.

by Julius Clemence R Hafalla, Karolis Bauza, Johannes Friesen, Gloria Gonzalez-Aseguinolaza, Adrian V S Hill, Kai Matuschewski
Published 2013-05-01

Heme oxygenase-1 inducer hemin does not inhibit SARS-CoV-2 virus infection

by Sheila Maestro, Karol M. Córdoba, Cristina Olague, Josepmaria Argemi, Matías A. Ávila, Gloria González-Aseguinolaza, Cristian Smerdou, Antonio Fontanellas
Published 2021-05-01

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

by Nicholas D. Weber, Leticia Odriozola, Javier Martínez-García, Veronica Ferrer, Anne Douar, Bernard Bénichou, Gloria González-Aseguinolaza, Cristian Smerdou
Published 2019-12-01

Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium.

by Dolores Rodríguez, Gloria González-Aseguinolaza, Juan R Rodríguez, Aneesh Vijayan, Magdalena Gherardi, Paloma Rueda, J Ignacio Casal, Mariano Esteban
Published 2012-01-01

Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.

by Paula S Montenegro-Miranda, Astrid Pañeda, Lysbeth ten Bloemendaal, Suzanne Duijst, Dirk R de Waart, Gloria Gonzalez- Aseguinolaza, Piter J Bosma
Published 2013-01-01

AAV-HDV: An Attractive Platform for the In Vivo Study of HDV Biology and the Mechanism of Disease Pathogenesis

by Sheila Maestro, Nahia Gómez-Echarte, Gracián Camps, Carla Usai, Lester Suárez, África Vales, Cristina Olagüe, Rafael Aldabe, Gloria González-Aseguinolaza
Published 2021-04-01

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

by Carla Usai, Sheila Maestro, Gracian Camps, Cristina Olague, Lester Suárez-Amaran, Africa Vales, Tomas Aragon, Mirja Hommel, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza
Published 2020-06-01

IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.

by Irene Gil-Fariña, Marianna Di Scala, Lucia Vanrell, Cristina Olagüe, Africa Vales, Katherine A High, Jesus Prieto, Federico Mingozzi, Gloria Gonzalez-Aseguinolaza
Published 2013-01-01

A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling.

by Estanislao Nistal-Villan, Joanna Poutou, Estefania Rodríguez-Garcia, Maria Buñuales, Beatriz Carte-Abad, Jesus Prieto, Gloria Gonzalez-Aseguinolaza, Ruben Hernandez-Alcoceba, Esther Larrea
Published 2016-01-01

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

by Andrea Raposo Lopez-Pastor, Almudena Gomez-Hernandez, Sabela Diaz-Castroverde, Gloria Gonzalez-Aseguinolaza, Agueda Gonzalez-Rodriguez, Gema Garcia, Silvia Fernandez, Oscar Escribano, Manuel Benito
Published 2019-02-01

Inhibition of MicroRNA 6937 Delays Photoreceptor and Vision Loss in a Mouse Model of Retinitis Pigmentosa

by Ander Anasagasti, Araceli Lara-López, Santiago Milla-Navarro, Leire Escudero-Arrarás, María Rodríguez-Hidalgo, Nerea Zabaleta, Gloria González Aseguinolaza, Pedro de la Villa, Javier Ruiz-Ederra
Published 2020-09-01

Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques

by Diego Sucunza, Alberto J. Rico, Elvira Roda, María Collantes, Gloria González-Aseguinolaza, Ana I. Rodríguez-Pérez, Iván Peñuelas, Alfonso Vázquez, José L. Labandeira-García, Vania Broccoli, José L. Lanciego
Published 2021-05-01

Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity

by Moanaro Biswas, Damien Marsic, Ning Li, Chenhui Zou, Gloria Gonzalez-Aseguinolaza, Irene Zolotukhin, Sandeep R.P. Kumar, Jyoti Rana, John S.S. Butterfield, Oleksandr Kondratov, Ype P. de Jong, Roland W. Herzog, Sergei Zolotukhin
Published 2020-12-01

Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis

by Sara Lumbreras, Ana Ricobaraza, Lucia Baila-Rueda, Manuela Gonzalez-Aparicio, Lucia Mora-Jimenez, Iker Uriarte, Maria Bunuales, Matias A. Avila, Maria J. Monte, Jose J.G. Marin, Ana Cenarro, Gloria Gonzalez-Aseguinolaza, Ruben Hernandez-Alcoceba
Published 2021-09-01

In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9

by Sergio López-Manzaneda, Isabel Ojeda-Pérez, Nerea Zabaleta, Aída García-Torralba, Omaira Alberquilla, Raúl Torres, Rebeca Sánchez-Domínguez, Laura Torella, Emmanuel Olivier, Joanne Mountford, Juan C. Ramírez, Juan A. Bueren, Gloria González-Aseguinolaza, Jose-Carlos Segovia
Published 2020-12-01

Multifaceted effects of soluble human CD6 in experimental cancer models

by Inês T Simões, Fernando Aranda, Sergi Casadó-Llombart, María Velasco-de Andrés, Cristina Català, Pilar Álvarez, Marta Consuegra-Fernández, Marc Orta-Mascaró, Ramón Merino, Jesús Merino, José Alberola-Ila, Gloria González-Aseguinolaza, Esther Carreras, Vanesa Martínez, Francisco Lozano
Published 2020-06-01

Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice

by Sabela Diaz-Castroverde, Almudena Gómez-Hernández, Silvia Fernández, Gema García-Gómez, Marianna Di Scala, Gloria González-Aseguinolaza, Elisa Fernández-Millán, Águeda González-Rodríguez, María García-Bravo, Pierre Chambon, Carmen Álvarez, Liliana Perdomo, Nuria Beneit, Oscar Escribano, Manuel Benito
Published 2016-11-01

CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I

by Nerea Zabaleta, Miren Barberia, Cristina Martin-Higueras, Natalia Zapata-Linares, Isabel Betancor, Saray Rodriguez, Rebeca Martinez-Turrillas, Laura Torella, Africa Vales, Cristina Olagüe, Amaia Vilas-Zornoza, Laura Castro-Labrador, David Lara-Astiaso, Felipe Prosper, Eduardo Salido, Gloria Gonzalez-Aseguinolaza, Juan R. Rodriguez-Madoz
Published 2018-12-01