Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

by Jonathan E Foley, Jing-Ruey J Yeh, Morgan L Maeder, Deepak Reyon, Jeffry D Sander, Randall T Peterson, J Keith Joung
Published 2009-01-01

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos.

by Mario Hermann, Morgan L Maeder, Kyle Rector, Joseph Ruiz, Burkhard Becher, Kurt Bürki, Cyd Khayter, Adriano Aguzzi, J Keith Joung, Thorsten Buch, Pawel Pelczar
Published 2012-01-01

Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

by Finola E Moore, Deepak Reyon, Jeffry D Sander, Sarah A Martinez, Jessica S Blackburn, Cyd Khayter, Cherie L Ramirez, J Keith Joung, David M Langenau
Published 2012-01-01

Heritable and precise zebrafish genome editing using a CRISPR-Cas system.

by Woong Y Hwang, Yanfang Fu, Deepak Reyon, Morgan L Maeder, Prakriti Kaini, Jeffry D Sander, J Keith Joung, Randall T Peterson, Jing-Ruey Joanna Yeh
Published 2013-01-01

Nodal patterning without Lefty inhibitory feedback is functional but fragile

by Katherine W Rogers, Nathan D Lord, James A Gagnon, Andrea Pauli, Steven Zimmerman, Deniz C Aksel, Deepak Reyon, Shengdar Q Tsai, J Keith Joung, Alexander F Schier
Published 2017-12-01

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

by Jonathan Y. Hsu, Julian Grünewald, Regan Szalay, Justine Shih, Andrew V. Anzalone, Kin Chung Lam, Max W. Shen, Karl Petri, David R. Liu, J. Keith Joung, Luca Pinello
Published 2021-02-01

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.

by Jeongeun Lee, Andrew S Hirsh, Ben S Wittner, Morgan L Maeder, Rajasekhar Singavarapu, Magdalena Lang, Sailajah Janarthanan, Ultan McDermott, Vijay Yajnik, Sridhar Ramaswamy, J Keith Joung, Dennis C Sgroi
Published 2011-01-01

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

by Shamim H Rahman, Johannes Kuehle, Christian Reimann, Tafadzwa Mlambo, Jamal Alzubi, Morgan L Maeder, Heimo Riedel, Paul Fisch, Tobias Cantz, Cornelia Rudolph, Claudio Mussolino, J Keith Joung, Axel Schambach, Toni Cathomen
Published 2015-05-01

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

by Bence György, Camilla Lööv, Mikołaj P. Zaborowski, Shuko Takeda, Benjamin P. Kleinstiver, Caitlin Commins, Ksenia Kastanenka, Dakai Mu, Adrienn Volak, Vilmantas Giedraitis, Lars Lannfelt, Casey A. Maguire, J. Keith Joung, Bradley T. Hyman, Xandra O. Breakefield, Martin Ingelsson
Published 2018-06-01

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function

by Lilian Cruz, Bence György, Pike See Cheah, Benjamin P. Kleinstiver, William A. Eimer, Sara P. Garcia, Nutan Sharma, Laurie J. Ozelius, D. Cristopher Bragg, J. Keith Joung, Osmar Norberto de Souza, Luis Fernando Saraiva Macedo Timmers, Xandra O. Breakefield
Published 2020-09-01

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

by Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Published 2020-07-01

High levels of AAV vector integration into CRISPR-induced DNA breaks

by Killian S. Hanlon, Benjamin P. Kleinstiver, Sara P. Garcia, Mikołaj P. Zaborowski, Adrienn Volak, Stefan E. Spirig, Alissa Muller, Alexander A. Sousa, Shengdar Q. Tsai, Niclas E. Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S. Chamberlain, David P. Corey, Martin J. Aryee, J. Keith Joung, Xandra O. Breakefield, Casey A. Maguire, Bence György
Published 2019-09-01