Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype

by Emily Peak, Karl F Hoffmann
Published 2011-06-01

Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability.

by Emily Peak, Iain W Chalmers, Karl F Hoffmann
Published 2010-07-01

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities [version 1; peer review: 1 approved, 2 approved with reservations...

by Gilda Padalino, Iain W. Chalmers, Andrea Brancale, Karl F. Hoffmann
Published 2020-07-01

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities [version 2; peer review: 1 approved, 2 approved with reservations...

by Gilda Padalino, Iain W. Chalmers, Andrea Brancale, Karl F. Hoffmann
Published 2020-11-01

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

by Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann
Published 2018-12-01

The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica.

by Jennifer Edwards, Martha Brown, Emily Peak, Barbara Bartholomew, Robert J Nash, Karl F Hoffmann
Published 2015-03-01

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

by Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann
Published 2018-06-01

Use of genomic DNA as an indirect reference for identifying gender-associated transcripts in morphologically identical, but chromosomally distinct, Schistosoma mansoni cercariae.

by Jennifer M Fitzpatrick, Anna V Protasio, Andrew J McArdle, Gary A Williams, David A Johnston, Karl F Hoffmann
Published 2008-01-01

The Anti-mycobacterial Activity of a Diterpenoid-Like Molecule Operates Through Nitrogen and Amino Acid Starvation

by Alessandra Crusco, Alessandra Crusco, Rafael Baptista, Sumana Bhowmick, Manfred Beckmann, Luis A. J. Mur, Andrew D. Westwell, Karl F. Hoffmann
Published 2019-06-01

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.

by Holly M Craven, Riccardo Bonsignore, Vasilis Lenis, Nicolo Santi, Daniel Berrar, Martin Swain, Helen Whiteland, Angela Casini, Karl F Hoffmann
Published 2021-02-01

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.

by Helen Whiteland, Alessandra Crusco, Lisa W Bloemberg, Jamie Tibble-Howlings, Josephine Forde-Thomas, Avril Coghlan, Patrick J Murphy, Karl F Hoffmann
Published 2020-10-01

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses.

by Jennifer M Fitzpatrick, Emily Peak, Samirah Perally, Iain W Chalmers, John Barrett, Timothy P Yoshino, Alasdair C Ivens, Karl F Hoffmann
Published 2009-11-01

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

by Kathrin K. Geyer, Sabrina E. Munshi, Martin Vickers, Michael Squance, Toby J. Wilkinson, Daniel Berrar, Cristian Chaparro, Martin T. Swain, Karl F. Hoffmann
Published 2018-08-01

The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses.

by Colin M Fitzsimmons, Frances M Jones, Alex Stearn, Iain W Chalmers, Karl F Hoffmann, Jakub Wawrzyniak, Shona Wilson, Narcis B Kabatereine, David W Dunne
Published 2012-01-01

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni.

by David Roquis, Aaron Taudt, Kathrin K Geyer, Gilda Padalino, Karl F Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto
Published 2018-05-01

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

by Kezia C L Whatley, Gilda Padalino, Helen Whiteland, Kathrin K Geyer, Benjamin J Hulme, Iain W Chalmers, Josephine Forde-Thomas, Salvatore Ferla, Andrea Brancale, Karl F Hoffmann
Published 2019-11-01

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

by Fanny C. Nowacki, Martin T. Swain, Oleg I. Klychnikov, Umar Niazi, Alasdair Ivens, Juan F. Quintana, Paul J. Hensbergen, Cornelis H. Hokke, Amy H. Buck, Karl F. Hoffmann
Published 2015-10-01

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment.

by Iain W Chalmers, Colin M Fitzsimmons, Martha Brown, Christine Pierrot, Frances M Jones, Jakub M Wawrzyniak, Narcis Fernandez-Fuentes, Edridah M Tukahebwa, David W Dunne, Jamal Khalife, Karl F Hoffmann
Published 2015-01-01

An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistoso...

by Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann
Published 2018-12-01

Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7.

by Natalie Reimers, Arne Homann, Beate Höschler, Kristina Langhans, R Alan Wilson, Christine Pierrot, Jamal Khalife, Christoph G Grevelding, Iain W Chalmers, Maria Yazdanbakhsh, Karl F Hoffmann, Cornelis H Hokke, Helmut Haas, Gabriele Schramm
Published 2015-03-01