Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis

by Sung-Young Shin, Lan K. Nguyen
Published 2016-08-01

Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network

by Milad Ghomlaghi, Anthony Hart, Nhan Hoang, Sungyoung Shin, Lan K. Nguyen
Published 2021-06-01

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.

by Sung-Young Shin, Anna-Katharina Müller, Nandini Verma, Sima Lev, Lan K Nguyen
Published 2018-06-01

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

by Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K. Nguyen, Michael Lazarou
Published 2019-01-01

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system.

by Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko
Published 2011-12-01

Polyubiquitin chain assembly and organisation determine the dynamics of protein activation and degradation

by Lan K. Nguyen, Maciej eDobrzynski, Dirk eFey, Boris N Kholodenko, Boris N Kholodenko, Boris N Kholodenko
Published 2014-01-01

SARAH Domain-Mediated MST2-RASSF Dimeric Interactions.

by Goar Sánchez-Sanz, Bartłomiej Tywoniuk, David Matallanas, David Romano, Lan K Nguyen, Boris N Kholodenko, Edina Rosta, Walter Kolch, Nicolae-Viorel Buchete
Published 2016-10-01

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

by Javier Rodriguez, Ruth Pilkington, Amaya Garcia Munoz, Lan K. Nguyen, Nora Rauch, Susan Kennedy, Naser Monsefi, Ana Herrero, Cormac T. Taylor, Alex von Kriegsheim
Published 2016-03-01

FGFR3 signaling and function in triple negative breast cancer

by Nicole J. Chew, Elizabeth V. Nguyen, Shih-Ping Su, Karel Novy, Howard C. Chan, Lan K. Nguyen, Jennii Luu, Kaylene J. Simpson, Rachel S. Lee, Roger J. Daly
Published 2020-01-01

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression

by Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Published 2021-02-01

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

by Alison L Kearney, Dougall M Norris, Milad Ghomlaghi, Martin Kin Lok Wong, Sean J Humphrey, Luke Carroll, Guang Yang, Kristen C Cooke, Pengyi Yang, Thomas A Geddes, Sungyoung Shin, Daniel J Fazakerley, Lan K Nguyen, David E James, James G Burchfield
Published 2021-07-01

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

by Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Published 2019-12-01