Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular Vesicles

by Laura C. Zanetti-Domingues, Scott E. Bonner, Marisa L. Martin-Fernandez, Veronica Huber
Published 2020-11-01

Hydrophobic fluorescent probes introduce artifacts into single molecule tracking experiments due to non-specific binding.

by Laura C Zanetti-Domingues, Christopher J Tynan, Daniel J Rolfe, David T Clarke, Marisa Martin-Fernandez
Published 2013-01-01

Cooperation and Interplay between EGFR Signalling and Extracellular Vesicle Biogenesis in Cancer

by Laura C. Zanetti-Domingues, Scott E. Bonner, R. Sumanth Iyer, Marisa L. Martin-Fernandez, Veronica Huber
Published 2020-12-01

A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking.

by Laura C Zanetti-Domingues, Marisa L Martin-Fernandez, Sarah R Needham, Daniel J Rolfe, David T Clarke
Published 2012-01-01

Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer

by Marisa L. Martin-Fernandez, David T. Clarke, Selene K. Roberts, Laura C. Zanetti-Domingues, Francesco L. Gervasio
Published 2019-04-01

Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.

by Sarah R Needham, Michael Hirsch, Daniel J Rolfe, David T Clarke, Laura C Zanetti-Domingues, Richard Wareham, Marisa L Martin-Fernandez
Published 2013-01-01

A global sampler of single particle tracking solutions for single molecule microscopy.

by Michael Hirsch, Richard Wareham, Ji W Yoon, Daniel J Rolfe, Laura C Zanetti-Domingues, Michael P Hobson, Peter J Parker, Marisa L Martin-Fernandez, Sumeetpal S Singh
Published 2019-01-01

Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress

by Luiza Mendonça, Andrew Howe, James B. Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L. Knight, Laura C. Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D. Li, Tao Ni, Ilias Kounatidis, Mohamed A. Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L. Martin-Fernandez, William James, Peijun Zhang
Published 2021-07-01

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

by Jeroen Claus, Gargi Patel, Flavia Autore, Audrey Colomba, Gregory Weitsman, Tanya N Soliman, Selene Roberts, Laura C Zanetti-Domingues, Michael Hirsch, Francesca Collu, Roger George, Elena Ortiz-Zapater, Paul R Barber, Boris Vojnovic, Yosef Yarden, Marisa L Martin-Fernandez, Angus Cameron, Franca Fraternali, Tony Ng, Peter J Parker
Published 2018-05-01

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

by Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Published 2016-10-01

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

by Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Published 2018-10-01

Affimer proteins are versatile and renewable affinity reagents

by Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca Ross, Danah AlQallaf, Ashley PE Roberts, Alexander Balls, Alistair Curd, Ruth E Hughes, Heather Martin, Sarah R Needham, Laura C Zanetti-Domingues, Yashar Sadigh, Thomas P Peacock, Anna A Tang, Naomi Gibson, Hannah Kyle, Geoffrey W Platt, Nicola Ingram, Thomas Taylor, Louise P Coletta, Iain Manfield, Margaret Knowles, Sandra Bell, Filomena Esteves, Azhar Maqbool, Raj K Prasad, Mark Drinkhill, Robin S Bon, Vikesh Patel, Sarah A Goodchild, Marisa Martin-Fernandez, Ray J Owens, Joanne E Nettleship, Michael E Webb, Michael Harrison, Jonathan D Lippiat, Sreenivasan Ponnambalam, Michelle Peckham, Alastair Smith, Paul Ko Ferrigno, Matt Johnson, Michael J McPherson, Darren Charles Tomlinson
Published 2017-06-01