The ROCKs on which tumour cells thrive

by Simon Wilkinson, Margaret C Frame
Published 2016-03-01

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.

by Kathryn Graham, Kim Moran-Jones, Owen J Sansom, Valerie G Brunton, Margaret C Frame
Published 2011-01-01

The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells.

by Joëlle Mounier, Michel R Popoff, Jost Enninga, Margaret C Frame, Philippe J Sansonetti, Guy Tran Van Nhieu
Published 2009-01-01

The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells

by Valerie G. Brunton, Valerie J. Fincham, Gordon W. McLean, Steven J. Winder, Christos Paraskeva, John F. Marshall, Margaret C. Frame
Published 2001-01-01

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

by Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
Published 2017-03-01

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs

by Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame
Published 2021-01-01

Diversity of matriptase expression level and function in breast cancer.

by Arkadiusz Welman, Duncan Sproul, Peter Mullen, Morwenna Muir, Andrew R Kinnaird, David J Harrison, Dana Faratian, Valerie G Brunton, Margaret C Frame
Published 2012-01-01

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

by Georgios Kanellos, Jing Zhou, Hitesh Patel, Rachel A. Ridgway, David Huels, Christine B. Gurniak, Emma Sandilands, Neil O. Carragher, Owen J. Sansom, Walter Witke, Valerie G. Brunton, Margaret C. Frame
Published 2015-12-01

The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1...

by Kristin A Sauter, Clare Pridans, Anuj Sehgal, Calum C Bain, Charlotte Scott, Lindsey Moffat, Rocío Rojo, Ben M Stutchfield, Claire L Davies, David S Donaldson, Kathleen Renault, Barry W McColl, Alan M Mowat, Alan Serrels, Margaret C Frame, Neil A Mabbott, David A Hume
Published 2014-01-01

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

by Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
Published 2021-06-01