Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

by Jakob C. Stüber, Christian P. Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Published 2021-06-01

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

by Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C. Schaefer, Wouter P. R. Verdurmen, Jonas V. Schaefer, Annemarie Honegger, Andreas Plückthun
Published 2016-06-01

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

by Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Published 2021-06-01