Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

by Wang-Yong Yang, Rui Gao, Mark Southern, Partha S. Sarkar, Matthew D. Disney
Published 2016-06-01

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology.

by Jonathan L Chen, Walter N Moss, Adam Spencer, Peiyuan Zhang, Jessica L Childs-Disney, Matthew D Disney
Published 2019-01-01

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression.

by Collin A O'Leary, Ryan J Andrews, Van S Tompkins, Jonathan L Chen, Jessica L Childs-Disney, Matthew D Disney, Walter N Moss
Published 2019-01-01

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

by Sai Pradeep Velagapudi, Yiling Luo, Tuan Tran, Hafeez S. Haniff, Yoshio Nakai, Mohammad Fallahi, Gustavo J. Martinez, Jessica L. Childs-Disney, Matthew D. Disney
Published 2017-03-01

Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome

by Chantal Sellier, Fernande Freyermuth, Ricardos Tabet, Tuan Tran, Fang He, Frank Ruffenach, Violaine Alunni, Herve Moine, Christelle Thibault, Adeline Page, Flora Tassone, Rob Willemsen, Matthew D. Disney, Paul J. Hagerman, Peter K. Todd, Nicolas Charlet-Berguerand
Published 2013-03-01

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

by Jeannie Chew, Casey Cook, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Lillian M. Daughrity, Monica Castanedes-Casey, Aishe Kurti, Jeannette N. Stankowski, Matthew D. Disney, Jeffrey D. Rothstein, Dennis W. Dickson, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Published 2019-02-01

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo

by Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Published 2020-05-01