Gene expression profiling in cells with enhanced gamma-secretase activity.

by Alexandra I Magold, Matthias Cacquevel, Patrick C Fraering
Published 2009-09-01

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

by Matthias Cacquevel, Lorène Aeschbach, Jemila Houacine, Patrick C Fraering
Published 2012-01-01

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

by Gabriele Siegel, Hermeto Gerber, Philipp Koch, Oliver Bruestle, Patrick C. Fraering, Lawrence Rajendran
Published 2017-06-01

A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

by Yufei Ren, Shun-Ho Huang, Sébastien Mosser, Marc Olivier Heuschkel, Arnaud Bertsch, Patrick C. Fraering, Jia-Jin Jason Chen, Philippe Renaud
Published 2015-12-01

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

by Hermeto Gerber, Sebastien Mosser, Benjamin Boury-Jamot, Michael Stumpe, Alessandra Piersigilli, Christine Goepfert, Joern Dengjel, Urs Albrecht, Fulvio Magara, Patrick C. Fraering
Published 2019-01-01

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

by Simona Eleuteri, Saviana Di Giovanni, Edward Rockenstein, Mike Mante, Antony Adame, Margarita Trejo, Wolf Wrasidlo, Fang Wu, Patrick C. Fraering, Eliezer Masliah, Hilal A. Lashuel
Published 2015-02-01