Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

by Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont
Published 2019-11-01

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

by Pierre Gantner, Amélie Pagliuzza, Marion Pardons, Moti Ramgopal, Jean-Pierre Routy, Rémi Fromentin, Nicolas Chomont
Published 2020-08-01

Fingolimod inhibits multiple stages of the HIV-1 life cycle.

by Rachel S Resop, Rémi Fromentin, Daniel Newman, Hawley Rigsby, Larisa Dubrovsky, Michael Bukrinsky, Nicolas Chomont, Alberto Bosque
Published 2020-08-01

Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.

by Emily S Ryan, Luca Micci, Rémi Fromentin, Sara Paganini, Colleen S McGary, Kirk Easley, Nicolas Chomont, Mirko Paiardini
Published 2016-02-01

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

by Marion Pardons, Amy E Baxter, Marta Massanella, Amélie Pagliuzza, Rémi Fromentin, Caroline Dufour, Louise Leyre, Jean-Pierre Routy, Daniel E Kaufmann, Nicolas Chomont
Published 2019-02-01

Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy.

by Sulggi A Lee, Peter Bacchetti, Nicolas Chomont, Remi Fromentin, Sharon R Lewin, Una O'Doherty, Sarah Palmer, Douglas D Richman, Janet D Siliciano, Steven A Yukl, Steven G Deeks, Peter D Burbelo
Published 2016-01-01

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

by Eunok Lee, Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer, Sarah Palmer
Published 2019-09-01

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals

by Rémi Fromentin, Sandrina DaFonseca, Cecilia T. Costiniuk, Mohamed El-Far, Francesco Andrea Procopio, Frederick M. Hecht, Rebecca Hoh, Steven G. Deeks, Daria J. Hazuda, Sharon R. Lewin, Jean-Pierre Routy, Rafick-Pierre Sékaly, Nicolas Chomont
Published 2019-02-01

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

by Rémi Fromentin, Wendy Bakeman, Mariam B Lawani, Gabriela Khoury, Wendy Hartogensis, Sandrina DaFonseca, Marisela Killian, Lorrie Epling, Rebecca Hoh, Elizabeth Sinclair, Frederick M Hecht, Peter Bacchetti, Steven G Deeks, Sharon R Lewin, Rafick-Pierre Sékaly, Nicolas Chomont
Published 2016-07-01

Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy

by Julia Niessl, Amy E. Baxter, Antigoni Morou, Elsa Brunet-Ratnasingham, Gérémy Sannier, Gabrielle Gendron-Lepage, Jonathan Richard, Gloria-Gabrielle Delgado, Nathalie Brassard, Isabelle Turcotte, Rémi Fromentin, Nicole F. Bernard, Nicolas Chomont, Jean-Pierre Routy, Mathieu Dubé, Andrés Finzi, Daniel E. Kaufmann
Published 2020-04-01

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants

by Bonnie Hiener, Bethany A. Horsburgh, John-Sebastian Eden, Kirston Barton, Timothy E. Schlub, Eunok Lee, Susanne von Stockenstrom, Lina Odevall, Jeffrey M. Milush, Teri Liegler, Elizabeth Sinclair, Rebecca Hoh, Eli A. Boritz, Daniel Douek, Rémi Fromentin, Nicolas Chomont, Steven G. Deeks, Frederick M. Hecht, Sarah Palmer
Published 2017-10-01

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.

by Ole S Søgaard, Mette E Graversen, Steffen Leth, Rikke Olesen, Christel R Brinkmann, Sara K Nissen, Anne Sofie Kjaer, Mariane H Schleimann, Paul W Denton, William J Hey-Cunningham, Kersten K Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A Rasmussen, Lars Østergaard, Martin Tolstrup
Published 2015-09-01

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

by Francesco Andrea Procopio, Rémi Fromentin, Deanna A. Kulpa, Jessica H. Brehm, Anne-Gaelle Bebin, Matthew C. Strain, Douglas D. Richman, Una O'Doherty, Sarah Palmer, Frederick M. Hecht, Rebecca Hoh, Richard J.O. Barnard, Michael D. Miller, Daria J. Hazuda, Steven G. Deeks, Rafick-Pierre Sékaly, Nicolas Chomont
Published 2015-08-01

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A cas...

by Nathan W Cummins, Stacey Rizza, Mark R Litzow, Stephane Hua, Guinevere Q Lee, Kevin Einkauf, Tae-Wook Chun, Frank Rhame, Jason V Baker, Michael P Busch, Nicolas Chomont, Patrick G Dean, Rémi Fromentin, Ashley T Haase, Dylan Hampton, Sheila M Keating, Steven M Lada, Tzong-Hae Lee, Sekar Natesampillai, Douglas D Richman, Timothy W Schacker, Stephen Wietgrefe, Xu G Yu, Joseph D Yao, John Zeuli, Mathias Lichterfeld, Andrew D Badley
Published 2017-11-01

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy.

by Julian H Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J Cameron, Miranda Z Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H Prince, Jennifer F Hoy, Nicolas Chomont, Rémi Fromentin, Francesco A Procopio, Joumana Zeidan, Sarah Palmer, Lina Odevall, Ricky W Johnstone, Ben P Martin, Elizabeth Sinclair, Steven G Deeks, Daria J Hazuda, Paul U Cameron, Rafick-Pierre Sékaly, Sharon R Lewin
Published 2014-10-01

HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

by Timothy J Henrich, Hiroyu Hatano, Oliver Bacon, Louise E Hogan, Rachel Rutishauser, Alison Hill, Mary F Kearney, Elizabeth M Anderson, Susan P Buchbinder, Stephanie E Cohen, Mohamed Abdel-Mohsen, Christopher W Pohlmeyer, Remi Fromentin, Rebecca Hoh, Albert Y Liu, Joseph M McCune, Jonathan Spindler, Kelly Metcalf-Pate, Kristen S Hobbs, Cassandra Thanh, Erica A Gibson, Daniel R Kuritzkes, Robert F Siliciano, Richard W Price, Douglas D Richman, Nicolas Chomont, Janet D Siliciano, John W Mellors, Steven A Yukl, Joel N Blankson, Teri Liegler, Steven G Deeks
Published 2017-11-01