Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells

by Stephanie S. Pavlovich, Stephanie S. Pavlovich, Tamarand Darling, Adam J. Hume, Adam J. Hume, Robert A. Davey, Robert A. Davey, Robert A. Davey, Feng Feng, Elke Mühlberger, Elke Mühlberger, Thomas B. Kepler, Thomas B. Kepler, Thomas B. Kepler
Published 2020-03-01

Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes.

by Mohammad F Saeed, Andrey A Kolokoltsov, Thomas Albrecht, Robert A Davey
Published 2010-09-01

Automation of Infectious Focus Assay for Determination of Filovirus Titers and Direct Comparison to Plaque and TCID₅₀ Assays

by Patrick T. Keiser, Manu Anantpadma, Hilary Staples, Ricardo Carrion, Robert A. Davey
Published 2021-01-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 2; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2016-01-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 1; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2015-10-01

Machine learning models identify molecules active against the Ebola virus in vitro [version 3; referees: 2 approved]

by Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter Madrid
Published 2017-01-01

Crimean-Congo hemorrhagic fever virus entry into host cells occurs through the multivesicular body and requires ESCRT regulators.

by Olena Shtanko, Raisa A Nikitina, Cengiz Z Altuntas, Alexander A Chepurnov, Robert A Davey
Published 2014-09-01

Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.

by Mohammad F Saeed, Andrey A Kolokoltsov, Alexander N Freiberg, Michael R Holbrook, Robert A Davey
Published 2008-08-01

Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus

by Qinghua Cui, Han Cheng, Rui Xiong, Gang Zhang, Ruikun Du, Manu Anantpadma, Robert A. Davey, Lijun Rong
Published 2018-11-01

Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism.

by Tonyia Eaves-Pyles, Heng-Fu Bu, Xiao-di Tan, Yingzi Cong, Jignesh Patel, Robert A Davey, Jane E Strasser
Published 2011-01-01

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

by Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A. Davey, Han Cheng, Lijun Rong
Published 2018-03-01

Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection.

by Thomas R Lane, Christopher Massey, Jason E Comer, Manu Anantpadma, Joel S Freundlich, Robert A Davey, Peter B Madrid, Sean Ekins
Published 2019-11-01

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

by Manu Anantpadma, Thomas Lane, Kimberley M. Zorn, Mary A. Lingerfelt, Alex M. Clark, Joel S. Freundlich, Robert A. Davey, Peter B. Madrid, Sean Ekins
Published 2019-01-01

Interferon-γ Inhibits Ebola Virus Infection.

by Bethany A Rhein, Linda S Powers, Kai Rogers, Manu Anantpadma, Brajesh K Singh, Yasuteru Sakurai, Thomas Bair, Catherine Miller-Hunt, Patrick Sinn, Robert A Davey, Martha M Monick, Wendy Maury
Published 2015-01-01

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

by Daisy W. Leung, Dominika Borek, Priya Luthra, Jennifer M. Binning, Manu Anantpadma, Gai Liu, Ian B. Harvey, Zhaoming Su, Ariel Endlich-Frazier, Juanli Pan, Reed S. Shabman, Wah Chiu, Robert A. Davey, Zbyszek Otwinowski, Christopher F. Basler, Gaya K. Amarasinghe
Published 2015-04-01

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents.

by Peter B Madrid, Sidharth Chopra, Ian D Manger, Lynne Gilfillan, Tiffany R Keepers, Amy C Shurtleff, Carol E Green, Lalitha V Iyer, Holli Hutcheson Dilks, Robert A Davey, Andrey A Kolokoltsov, Ricardo Carrion, Jean L Patterson, Sina Bavari, Rekha G Panchal, Travis K Warren, Jay B Wells, Walter H Moos, Raelyn L Burke, Mary J Tanga
Published 2013-01-01

Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.

by Dong-Hoon Chung, Colleen B Jonsson, Nichole A Tower, Yong-Kyu Chu, Ergin Sahin, Jennifer E Golden, James W Noah, Chad E Schroeder, Julie B Sotsky, Melinda I Sosa, Daniel E Cramer, Sara N McKellip, Lynn Rasmussen, E Lucile White, Connie S Schmaljohn, Justin G Julander, Jeffrey M Smith, Claire Marie Filone, John H Connor, Yasuteru Sakurai, Robert A Davey
Published 2014-06-01

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

by Christoph Gorgulla, Krishna M. Padmanabha Das, Kendra E. Leigh, Marco Cespugli, Patrick D. Fischer, Zi-Fu Wang, Guilhem Tesseyre, Shreya Pandita, Alec Shnapir, Anthony Calderaio, Minko Gechev, Alexander Rose, Noam Lewis, Colin Hutcheson, Erez Yaffe, Roni Luxenburg, Henry D. Herce, Vedat Durmaz, Thanos D. Halazonetis, Konstantin Fackeldey, J.J. Patten, Alexander Chuprina, Igor Dziuba, Alla Plekhova, Yurii Moroz, Dmytro Radchenko, Olga Tarkhanova, Irina Yavnyuk, Christian Gruber, Ryan Yust, Dave Payne, Anders M. Näär, Mark N. Namchuk, Robert A. Davey, Gerhard Wagner, Jamie Kinney, Haribabu Arthanari
Published 2021-02-01

Inhibition of HECT E3 ligases as potential therapy for COVID-19

by Giuseppe Novelli, Jing Liu, Michela Biancolella, Tonino Alonzi, Antonio Novelli, J. J. Patten, Dario Cocciadiferro, Emanuele Agolini, Vito Luigi Colona, Barbara Rizzacasa, Rosalinda Giannini, Benedetta Bigio, Delia Goletti, Maria Rosaria Capobianchi, Sandro Grelli, Justin Mann, Trevor D. McKee, Ke Cheng, Fatima Amanat, Florian Krammer, Andrea Guarracino, Gerardo Pepe, Carlo Tomino, Yacine Tandjaoui-Lambiotte, Yurdagul Uzunhan, Sarah Tubiana, Jade Ghosn, COVID Human Genetic Effort, French COVID Cohort Study Group, CoV-Contact Cohort, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Aurélie Cobat, Gai Elhanan, Joseph J. Grzymski, Andrea Latini, Sachdev S. Sidhu, Suresh Jain, Robert A. Davey, Jean-Laurent Casanova, Wenyi Wei, Pier Paolo Pandolfi
Published 2021-03-01

Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names

by Jens H. Kuhn, Kristian G. Andersen, Yīmíng Bào, Sina Bavari, Stephan Becker, Richard S. Bennett, Nicholas H. Bergman, Olga Blinkova, Steven Bradfute, J. Rodney Brister, Alexander Bukreyev, Kartik Chandran, Alexander A. Chepurnov, Robert A. Davey, Ralf G. Dietzgen, Norman A. Doggett, Olga Dolnik, John M. Dye, Sven Enterlein, Paul W. Fenimore, Pierre Formenty, Alexander N. Freiberg, Robert F. Garry, Nicole L. Garza, Stephen K. Gire, Jean-Paul Gonzalez, Anthony Griffiths, Christian T. Happi, Lisa E. Hensley, Andrew S. Herbert, Michael C. Hevey, Thomas Hoenen, Anna N. Honko, Georgy M. Ignatyev, Peter B. Jahrling, Joshua C. Johnson, Karl M. Johnson, Jason Kindrachuk, Hans-Dieter Klenk, Gary Kobinger, Tadeusz J. Kochel, Matthew G. Lackemeyer, Daniel F. Lackner, Eric M. Leroy, Mark S. Lever, Elke Mühlberger, Sergey V. Netesov, Gene G. Olinger, Sunday A. Omilabu, Gustavo Palacios, Rekha G. Panchal, Daniel J. Park, Jean L. Patterson, Janusz T. Paweska, Clarence J. Peters, James Pettitt, Louise Pitt, Sheli R. Radoshitzky, Elena I. Ryabchikova, Erica Ollmann Saphire, Pardis C. Sabeti, Rachel Sealfon, Aleksandr M. Shestopalov, Sophie J. Smither, Nancy J. Sullivan, Robert Swanepoel, Ayato Takada, Jonathan S. Towner, Guido van der Groen, Viktor E. Volchkov, Valentina A. Volchkova, Victoria Wahl-Jensen, Travis K. Warren, Kelly L. Warfield, Manfred Weidmann, Stuart T. Nichol
Published 2014-09-01