DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat

by Harvey Boughey, Mateusz Jurga, Sherif F. El-Khamisy
Published 2021-06-01

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.

by Meryem Alagoz, Shih-Chieh Chiang, Abhishek Sharma, Sherif F El-Khamisy
Published 2013-01-01

USP11 controls R-loops by regulating senataxin proteostasis

by Mateusz Jurga, Arwa A. Abugable, Alastair S. H. Goldman, Sherif F. El-Khamisy
Published 2021-09-01

Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

by Dalia Fleifel, Mai Atef Rahmoon, Abdelrahman AlOkda, Mostafa Nasr, Menattallah Elserafy, Sherif F. El-Khamisy
Published 2018-12-01

Integrative microRNA and gene expression analysis identifies new epigenetically regulated microRNAs mediating taxane resistance in ovarian cancer

by Mohamed K. Hassan, Amr A. Waly, Waheba Elsayed, Sarah Keshk, Walaa Ramadan Allam, Sherif F. El-khamisy
Published 2021-01-01

Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

by Angela E. M. Ibler, Mohamed ElGhazaly, Kathryn L. Naylor, Natalia A. Bulgakova, Sherif F. El-Khamisy, Daniel Humphreys
Published 2019-09-01

Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugsResearch in context

by Mohamed Tharwat Hegazy, Walaa Ramadan Allam, Mohamed A. Hussein, Naguib Zoheir, Luca Quartuccio, Sherif F. El-Khamisy, Gaafar Ragab
Published 2018-09-01

High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice

by Mohamed E. Ashour, Walaa Allam, Waheba Elsayed, Reham Atteya, Menattallah Elserafy, Sameh Magdeldin, Mohamed K. Hassan, Sherif F. El-Khamisy
Published 2021-05-01

UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis

by Chunyan Liao, Ryan Beveridge, Jessica J.R. Hudson, Jacob D. Parker, Shih-Chieh Chiang, Swagat Ray, Mohamed E. Ashour, Ian Sudbery, Mark J. Dickman, Sherif F. El-Khamisy
Published 2018-06-01

Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma

by Natasha Carmell, Ola Rominiyi, Katie N. Myers, Connor McGarrity-Cottrell, Aurelie Vanderlinden, Nikita Lad, Eva Perroux-David, Sherif F. El-Khamisy, Malee Fernando, Katherine G. Finegan, Stephen Brown, Spencer J. Collis
Published 2021-02-01

Hypoxia-induced SETX links replication stress with the unfolded protein response

by Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Published 2021-06-01

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

by John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan
Published 2020-03-01

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits

by Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena y Valenzuela, Ross A. Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F. El-Khamisy, Thomas H. Gillingwater, Pamela J. Shaw, Mimoun Azzouz
Published 2017-07-01

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN

by Abdelghani Mazouzi, Alexey Stukalov, André C. Müller, Doris Chen, Marc Wiedner, Jana Prochazkova, Shih-Chieh Chiang, Michael Schuster, Florian P. Breitwieser, Andreas Pichlmair, Sherif F. El-Khamisy, Christoph Bock, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou
Published 2016-04-01

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

by Hannah M. Southam, Thomas W. Smith, Rhiannon L. Lyon, Chunyan Liao, Clare R. Trevitt, Laurence A. Middlemiss, Francesca L. Cox, Jonathan A. Chapman, Sherif F. El-Khamisy, Michael Hippler, Michael P. Williamson, Peter J.F. Henderson, Robert K. Poole
Published 2018-09-01

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

by Guillaume M. Hautbergue, Lydia M. Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Adrian Higginbottom, Ya-Hui Lin, Claudia S. Bauer, Jennifer E. Dodd, Monika A. Myszczynska, Sarah M. Alam, Pierre Garneret, Jayanth S. Chandran, Evangelia Karyka, Matthew J. Stopford, Emma F. Smith, Janine Kirby, Kathrin Meyer, Brian K. Kaspar, Adrian M. Isaacs, Sherif F. El-Khamisy, Kurt J. De Vos, Ke Ning, Mimoun Azzouz, Alexander J. Whitworth, Pamela J. Shaw
Published 2017-07-01