Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis

by Visnja Radulovic, Mark van der Garde, Shuhei Koide, Valgardur Sigurdsson, Stefan Lang, Shin Kaneko, Kenichi Miharada
Published 2019-06-01

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

by Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama
Published 2018-11-01

The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

by Satoru Miyagi, Shuhei Koide, Atsunori Saraya, George R. Wendt, Motohiko Oshima, Takaaki Konuma, Satoshi Yamazaki, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Issay Kitabayashi, Hiromitsu Nakauchi, Atsushi Iwama
Published 2014-02-01

Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells.

by Tomoko Saito, Tetsuhiro Chiba, Kaori Yuki, Yoh Zen, Motohiko Oshima, Shuhei Koide, Tenyu Motoyama, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Akinobu Tawada, Motohisa Tada, Fumihiko Kanai, Yuichi Takiguchi, Atsushi Iwama, Osamu Yokosuka
Published 2013-01-01

Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

by Kengo Kanayama, Tetsuhiro Chiba, Motohiko Oshima, Hiroaki Kanzaki, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Naoya Mimura, Yuko Kusakabe, Tomoko Saito, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Hitoshi Maruyama, Atsushi Iwama, Naoya Kato
Published 2019-01-01

Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.

by Tetsuhiro Chiba, Eiichiro Suzuki, Kaori Yuki, Yoh Zen, Motohiko Oshima, Satoru Miyagi, Atsunori Saraya, Shuhei Koide, Tenyu Motoyama, Sadahisa Ogasawara, Yoshihiko Ooka, Akinobu Tawada, Tetsuya Nakatsura, Takehiro Hayashi, Taro Yamashita, Syuichi Kaneko, Masaru Miyazaki, Atsushi Iwama, Osamu Yokosuka
Published 2014-01-01

The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

by Yurie Nagai, Naoya Mimura, Ola Rizq, Yusuke Isshiki, Motohiko Oshima, Mohamed Rizk, Atsunori Saraya, Shuhei Koide, Yaeko Nakajima-Takagi, Makiko Miyota, Tetsuhiro Chiba, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru Iseki, Chiaki Nakaseko, William Lennox, Josephine Sheedy, Marla Weetall, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida
Published 2021-01-01