Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases

by Dorit Trudler, Swagata Ghatak, Stuart A. Lipton
Published 2021-07-01

Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases

by Mohd Waseem Akhtar, Carmen R. Sunico, Tomohiro Nakamura, Stuart A. Lipton
Published 2012-01-01

A Golgi fragmentation pathway in neurodegeneration

by Saya Nakagomi, Mark J. Barsoum, Ella Bossy-Wetzel, Christine Sütterlin, Vivek Malhotra, Stuart A. Lipton
Published 2008-02-01

Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential

by Takumi Satoh, Romain Stalder, Scott R. McKercher, Robert E. Williamson, Gregory P. Roth, Stuart A. Lipton
Published 2015-07-01

Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells

by Shing Fai Chan, Xiayu Huang, Scott R. McKercher, Rameez Zaidi, Shu-ichi Okamoto, Nobuki Nakanishi, Stuart A. Lipton
Published 2015-03-01

Genetic deletion of NR3A accelerates glutamatergic synapse maturation.

by Maile A Henson, Rylan S Larsen, Shelikha N Lawson, Isabel Pérez-Otaño, Nobuki Nakanishi, Stuart A Lipton, Benjamin D Philpot
Published 2012-01-01

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

by Swagata Ghatak, Nima Dolatabadi, Dorit Trudler, XiaoTong Zhang, Yin Wu, Madhav Mohata, Rajesh Ambasudhan, Maria Talantova, Stuart A Lipton
Published 2019-11-01

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

by Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki Ruoslahti
Published 2017-11-01

Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

by Aman P. Mann, Pablo Scodeller, Sazid Hussain, Gary B. Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A. Lipton, Erkki Ruoslahti
Published 2018-03-01

MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.

by Eun-Gyung Cho, Jeffrey D Zaremba, Scott R McKercher, Maria Talantova, Shichun Tu, Eliezer Masliah, Shing Fai Chan, Nobuki Nakanishi, Alexey Terskikh, Stuart A Lipton
Published 2011-01-01

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

by Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton
Published 2016-01-01

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

by Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton
Published 2015-12-01

The critical role of membralin in postnatal motor neuron survival and disease

by Bo Yang, Mingliang Qu, Rengang Wang, Jon E Chatterton, Xiao-Bo Liu, Bing Zhu, Sonoko Narisawa, Jose Luis Millan, Nobuki Nakanishi, Kathryn Swoboda, Stuart A Lipton, Dongxian Zhang
Published 2015-05-01

NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model

by Shu-ichi Okamoto, Olga Prikhodko, Juan Pina-Crespo, Anthony Adame, Scott R. McKercher, Laurence M. Brill, Nobuki Nakanishi, Chang-ki Oh, Tomohiro Nakamura, Eliezer Masliah, Stuart A. Lipton
Published 2019-07-01

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

by Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan
Published 2018-02-01

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

by Chang-Ki Oh, Abdullah Sultan, Joseph Platzer, Nima Dolatabadi, Frank Soldner, Daniel B. McClatchy, Jolene K. Diedrich, John R. Yates, III, Rajesh Ambasudhan, Tomohiro Nakamura, Rudolf Jaenisch, Stuart A. Lipton
Published 2017-11-01

Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling

by Ilyas Singec, Andrew M. Crain, Junjie Hou, Brian T.D. Tobe, Maria Talantova, Alicia A. Winquist, Kutbuddin S. Doctor, Jennifer Choy, Xiayu Huang, Esther La Monaca, David M. Horn, Dieter A. Wolf, Stuart A. Lipton, Gustavo J. Gutierrez, Laurence M. Brill, Evan Y. Snyder
Published 2016-09-01

S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death

by Shu-ichi Okamoto, Tomohiro Nakamura, Piotr Cieplak, Shing Fai Chan, Evgenia Kalashnikova, Lujian Liao, Sofiyan Saleem, Xuemei Han, Arjay Clemente, Anthony Nutter, Sam Sances, Christopher Brechtel, Daniel Haus, Florian Haun, Sara Sanz-Blasco, Xiayu Huang, Hao Li, Jeffrey D. Zaremba, Jiankun Cui, Zezong Gu, Rana Nikzad, Anne Harrop, Scott R. McKercher, Adam Godzik, John R. Yates III, Stuart A. Lipton
Published 2014-07-01

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

by Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Published 2017-11-01