Clinical Development of New TB Vaccines: Recent Advances and Next Steps

by Mark Hatherill, Richard G. White, Thomas R. Hawn
Published 2020-01-01

Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages

by D. Shane O'Mahony, Uyenvy Pham, Ramesh Iyer, Thomas R. Hawn, W. Conrad Liles
Published 2008-01-01

Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction.

by Elizabeth A Misch, Murdo Macdonald, Chaman Ranjit, Bishwa R Sapkota, Richard D Wells, M Ruby Siddiqui, Gilla Kaplan, Thomas R Hawn
Published 2008-05-01

Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.

by Thomas R Hawn, Delia Scholes, Hongwei Wang, Sue S Li, Ann E Stapleton, Marta Janer, Alan Aderem, Walter E Stamm, Lue Ping Zhao, Thomas M Hooton
Published 2009-12-01

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury.

by Paul L Bollyky, Jeffrey B Bice, Ian R Sweet, Ben A Falk, John A Gebe, April E Clark, Vivian H Gersuk, Alan Aderem, Thomas R Hawn, Gerald T Nepom
Published 2009-01-01

Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.

by Thomas R Hawn, Delia Scholes, Shuying S Li, Hongwei Wang, Yin Yang, Pacita L Roberts, Ann E Stapleton, Marta Janer, Alan Aderem, Walter E Stamm, Lue Ping Zhao, Thomas M Hooton
Published 2009-06-01

Differential dermal expression of CCL17 and CCL18 in tuberculoid and lepromatous leprosy.

by William R Berrington, Chhatra B Kunwar, Kapil Neupane, Susan J F van den Eeden, James C Vary, Glenna J Peterson, Richard D Wells, Annemieke Geluk, Deanna A Hagge, Thomas R Hawn
Published 2014-01-01

Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria.

by Andrew D Graustein, Elizabeth A Misch, Munyaradzi Musvosvi, Muki Shey, Javeed A Shah, Chetan Seshadri, Augustine Ajuogu, Kathryn Bowman, Humphrey Mulenga, Ashley Veldsman, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Thomas R Hawn
Published 2018-01-01

Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.

by Chetan Seshadri, Nafiseh Sedaghat, Monica Campo, Glenna Peterson, Richard D Wells, Gregory S Olson, David R Sherman, Catherine M Stein, Harriet Mayanja-Kizza, Ali Shojaie, W Henry Boom, Thomas R Hawn, Tuberculosis Research Unit (TBRU)
Published 2017-01-01

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

by April Kaur Randhawa, Muki S Shey, Alana Keyser, Blas Peixoto, Richard D Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A Hanekom, Thomas R Hawn, South African Tuberculosis Vaccine Initiative Team
Published 2011-08-01

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

by Juan S Ruiz-Moreno, Lutz Hamann, Javeed A Shah, Annelies Verbon, Frank P Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E Sander, Martin Witzenrath, John C Cambier, Norbert Suttorp, Ralf R Schumann, Lei Jin, Thomas R Hawn, Bastian Opitz, CAPNETZ Study Group
Published 2018-01-01

Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.

by Nguyen Thuy Thuong Thuong, Sarah J Dunstan, Tran Thi Hong Chau, Vesteinn Thorsson, Cameron P Simmons, Nguyen Than Ha Quyen, Guy E Thwaites, Nguyen Thi Ngoc Lan, Martin Hibberd, Yik Y Teo, Mark Seielstad, Alan Aderem, Jeremy J Farrar, Thomas R Hawn
Published 2008-12-01

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

by Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team
Published 2012-01-01

The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.

by Maxine Caws, Guy Thwaites, Sarah Dunstan, Thomas R Hawn, Nguyen Thi Ngoc Lan, Nguyen Thuy Thuong Thuong, Kasia Stepniewska, Mai Nguyet Thu Huyen, Nguyen Duc Bang, Tran Huu Loc, Sebastien Gagneux, Dick van Soolingen, Kristin Kremer, Marianne van der Sande, Peter Small, Phan Thi Hoang Anh, Nguyen Tran Chinh, Hoang Thi Quy, Nguyen Thi Hong Duyen, Dau Quang Tho, Nguyen T Hieu, Estee Torok, Tran Tinh Hien, Nguyen Huy Dung, Nguyen Thi Quynh Nhu, Phan Minh Duy, Nguyen van Vinh Chau, Jeremy Farrar
Published 2008-03-01