Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]

by Krista M. Schroeder, Thomas P. Beyer, Ryan J. Hansen, Bomie Han, Richard T. Pickard, Victor J. Wroblewski, Mark C. Kowala, Patrick I. Eacho
Published 2015-11-01

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys.

by Andrew C Adams, Carolyn A Halstead, Barbara C Hansen, Armando R Irizarry, Jennifer A Martin, Sharon R Myers, Vincent L Reynolds, Holly W Smith, Victor J Wroblewski, Alexei Kharitonenkov
Published 2013-01-01

Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.

by Alexei Kharitonenkov, John M Beals, Radmila Micanovic, Beth A Strifler, Radhakrishnan Rathnachalam, Victor J Wroblewski, Shun Li, Anja Koester, Amy M Ford, Tamer Coskun, James D Dunbar, Christine C Cheng, Christopher C Frye, Thomas F Bumol, David E Moller
Published 2013-01-01