An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

by Wai Hoong Chang, Alvina G. Lai
Published 2019-11-01

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cance...

by Wai Hoong Chang, Alvina G. Lai
Published 2020-08-01

A TALE of shrimps: Genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa [version 1; referees: 2 approved, 1 approved with reservations]

by Wai Hoong Chang, Alvina G. Lai
Published 2018-01-01

Comparative genomic analysis of crustacean hyperglycemic hormone (CHH) neuropeptide genes across diverse crustacean species [version 1; referees: 1 approved, 2 approved with reserv...

by Wai Hoong Chang, Alvina G. Lai
Published 2018-01-01

Genome-wide analyses of the bHLH superfamily in crustaceans: reappraisal of higher-order groupings and evidence for lineage-specific duplications

by Wai Hoong Chang, Alvina G. Lai
Published 2018-01-01

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

by Wai Hoong Chang, Alvina G. Lai
Published 2019-04-01

Mixed evolutionary origins of endogenous biomass-depolymerizing enzymes in animals

by Wai Hoong Chang, Alvina G. Lai
Published 2018-06-01

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

by Wai Hoong Chang, Donall Forde, Alvina G. Lai
Published 2019-01-01

Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project

by Yuguo Wei, Nikolaos Papachristou, Stefanie Mueller, Genomics England Research Consortium, Wai Hoong Chang, Alvina G. Lai
Published 2021-10-01

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen [version 1; referees: 2 approved]

by Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating
Published 2018-09-01

Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths...

by Richard D Neal, Amitava Banerjee, Deenan Pillay, Vahe Nafilyan, Clare Turnbull, Harry Hemingway, Bryan Williams, Mark Lawler, Spiros Denaxas, Kathy Pritchard-Jones, Mahdad Noursadeghi, Richard Sullivan, Graham R Foster, Ben Humberstone, Alvina G Lai, Laura Pasea, Wai Hoong Chang, Michail Katsoulis, David Linch, Derralynn Hughes, Martin D Forster, Natalie K Fitzpatrick, Kathryn Boyd, Tariq Enver, Matt Cooper, Charlie Davie
Published 2020-11-01

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

by Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating
Published 2019-01-01