Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Abstract Background Prolonged exposure to elevated free fatty acids induces β-cell failure (lipotoxicity) and contributes to the pathogenesis of type 2 diabetes. In vitro exposure of β-cells to the saturated free fatty acid palmitate is a valuable model of lipotoxicity, reproducing features of β-cel...

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Bibliographic Details
Main Authors: Maria Lytrivi, Kassem Ghaddar, Miguel Lopes, Victoria Rosengren, Anthony Piron, Xiaoyan Yi, Henrik Johansson, Janne Lehtiö, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Henrik Ortsäter, Decio L. Eizirik, Miriam Cnop
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Genomics
Subjects:
Pancreatic islets
Beta-cells
Free fatty acids
Lipid metabolism
Endoplasmic reticulum stress
RNA-sequencing
Online Access:http://link.springer.com/article/10.1186/s12864-020-07003-0

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http://link.springer.com/article/10.1186/s12864-020-07003-0

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