Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

by Neha Shrestha, Elisa De Franco, Peter Arvan, Peter Arvan, Miriam Cnop, Miriam Cnop
Published 2021-04-01

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

by Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Published 2017-09-01

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

by Maria Nicol Arroyo, Jonathan Alex Green, Miriam Cnop, Mariana Igoillo-Esteve
Published 2021-01-01

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

by Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published 2020-01-01

Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury.

by Eddy Himpe, Daniel A Cunha, Imane Song, Marco Bugliani, Piero Marchetti, Miriam Cnop, Luc Bouwens
Published 2016-01-01

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

by Stephanie Bourgeois, Toshiaki Sawatani, Annelore Van Mulders, Nico De Leu, Yves Heremans, Harry Heimberg, Miriam Cnop, Willem Staels
Published 2021-01-01

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

by Laura Marroqui, Matilde Masini, Beatriz Merino, Fabio A. Grieco, Isabelle Millard, Christine Dubois, Ivan Quesada, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published 2015-05-01

Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.

by Katleen Lemaire, Rodrigo F Moura, Mikaela Granvik, Mariana Igoillo-Esteve, Hans E Hohmeier, Nico Hendrickx, Christopher B Newgard, Etienne Waelkens, Miriam Cnop, Frans Schuit
Published 2011-04-01

Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas

by J. Geoffrey Chase, Thomas Desaive, Julien Bohe, Miriam Cnop, Christophe De Block, Jan Gunst, Roman Hovorka, Pierre Kalfon, James Krinsley, Eric Renard, Jean-Charles Preiser
Published 2018-08-01

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

by Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eizirik
Published 2013-05-01

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis

by Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli, Miriam Cnop, Decio L. Eizirik, Piero Marchetti, Lorella Marselli
Published 2021-02-01

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

by Maria Lytrivi, Kassem Ghaddar, Miguel Lopes, Victoria Rosengren, Anthony Piron, Xiaoyan Yi, Henrik Johansson, Janne Lehtiö, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Henrik Ortsäter, Decio L. Eizirik, Miriam Cnop
Published 2020-08-01

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.

by Mariana Igoillo-Esteve, Anne Genin, Nelle Lambert, Julie Désir, Isabelle Pirson, Baroj Abdulkarim, Nicolas Simonis, Anais Drielsma, Lorella Marselli, Piero Marchetti, Pierre Vanderhaeghen, Décio L Eizirik, Wim Wuyts, Cécile Julier, Ali J Chakera, Sian Ellard, Andrew T Hattersley, Marc Abramowicz, Miriam Cnop
Published 2013-10-01

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

by Décio L Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo-Esteve, Fernanda Ortis, Izortze Santin, Maikel L Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I McCarthy, Miriam Cnop
Published 2012-01-01

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

by Kashyap A. Patel, Jarno Kettunen, Markku Laakso, Alena Stančáková, Thomas W. Laver, Kevin Colclough, Matthew B. Johnson, Marc Abramowicz, Leif Groop, Päivi J. Miettinen, Maggie H. Shepherd, Sarah E. Flanagan, Sian Ellard, Nobuya Inagaki, Andrew T. Hattersley, Tiinamaija Tuomi, Miriam Cnop, Michael N. Weedon
Published 2017-10-01

Insulinoma Localization by Glucagon-Like Peptide-1 Receptor Imaging After 18 Years of Hypoglycemia

by Aglaia Kyrilli, MD, Mariana Igoillo-Esteve, PhD, Françoise Féry, MD, PhD, Fabio A. Grieco, PhD, Pierre Eisendrath, MD, Didier Blocklet, MD, Serge Goldman, MD, PhD, Jean-Claude Henquin, MD, PhD, Martin Gotthardt, MD, PhD, Miriam Cnop, MD, PhD
Published 2015-01-01

CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability

by Louise Montagne, Mehdi Derhourhi, Amélie Piton, Bénédicte Toussaint, Emmanuelle Durand, Emmanuel Vaillant, Dorothée Thuillier, Stefan Gaget, Franck De Graeve, Iandry Rabearivelo, Amélie Lansiaux, Bruno Lenne, Sylvie Sukno, Rachel Desailloud, Miriam Cnop, Ramona Nicolescu, Lior Cohen, Jean-François Zagury, Mélanie Amouyal, Jacques Weill, Jean Muller, Olivier Sand, Bruno Delobel, Philippe Froguel, Amélie Bonnefond
Published 2018-07-01

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

by Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L. Eizirik, Miriam Cnop, Piero Marchetti
Published 2020-12-01