Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes

by Maikel L. Colli, Florian Szymczak, Decio L. Eizirik, Decio L. Eizirik, Decio L. Eizirik
Published 2020-09-01

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.

by Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik
Published 2011-09-01

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

by Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eizirik
Published 2013-05-01

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

by Décio L Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo-Esteve, Fernanda Ortis, Izortze Santin, Maikel L Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I McCarthy, Miriam Cnop
Published 2012-01-01

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 inductionResearch in context

by Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Published 2018-10-01

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

by Daniela Fignani, Daniela Fignani, Giada Licata, Giada Licata, Noemi Brusco, Noemi Brusco, Laura Nigi, Laura Nigi, Giuseppina E. Grieco, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Decio L. Eizirik, Guido Sebastiani, Guido Sebastiani, Francesco Dotta, Francesco Dotta, Francesco Dotta
Published 2020-11-01

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

by Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lorenzo Pasquali, Décio L. Eizirik
Published 2020-05-01

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

by Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Peter Hecht, Brian Rady, Ivona Bakaj, Alessandro Pocai, Lisa Norquay, Bernard Thorens, Mickaël Canouil, Philippe Froguel, Decio L. Eizirik, Miriam Cnop, Piero Marchetti
Published 2020-12-01