Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes

by Maikel L. Colli, Florian Szymczak, Decio L. Eizirik, Decio L. Eizirik, Decio L. Eizirik
Published 2020-09-01

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

by Stephane Demine, Michael L. Schulte, Paul R. Territo, Decio L. Eizirik
Published 2020-10-01

Clic4, a novel protein that sensitizes β-cells to apoptosis

by Dhaval Patel, Damien Ythier, Flora Brozzi, Decio L. Eizirik, Bernard Thorens
Published 2015-04-01

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.

by Esteban N Gurzov, Fernanda Ortis, Latifa Bakiri, Erwin F Wagner, Decio L Eizirik
Published 2008-01-01

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells

by Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published 2020-01-01

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.

by Fabrice Moore, Izortze Santin, Tatiane C Nogueira, Esteban N Gurzov, Lorella Marselli, Piero Marchetti, Decio L Eizirik
Published 2012-01-01

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

by Laura Marroqui, Matilde Masini, Beatriz Merino, Fabio A. Grieco, Isabelle Millard, Christine Dubois, Ivan Quesada, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Published 2015-05-01

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

by Daniela Fignani, Daniela Fignani, Giada Licata, Giada Licata, Noemi Brusco, Noemi Brusco, Laura Nigi, Laura Nigi, Giuseppina E. Grieco, Giuseppina E. Grieco, Lorella Marselli, Lut Overbergh, Conny Gysemans, Maikel L. Colli, Piero Marchetti, Chantal Mathieu, Decio L. Eizirik, Decio L. Eizirik, Guido Sebastiani, Guido Sebastiani, Francesco Dotta, Francesco Dotta, Francesco Dotta
Published 2020-11-01

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

by Laura Marroqui, Miguel Lopes, Reinaldo S dos Santos, Fabio A Grieco, Merja Roivainen, Sarah J Richardson, Noel G Morgan, Anne Op de beeck, Decio L Eizirik
Published 2015-06-01

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.

by Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik
Published 2011-09-01

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

by Tania Quesada-López, Rubén Cereijo, Jean-Valery Turatsinze, Anna Planavila, Montserrat Cairó, Aleix Gavaldà-Navarro, Marion Peyrou, Ricardo Moure, Roser Iglesias, Marta Giralt, Decio L. Eizirik, Francesc Villarroya
Published 2016-11-01

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.

by Tatiane C Nogueira, Flavia M Paula, Olatz Villate, Maikel L Colli, Rodrigo F Moura, Daniel A Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L Eizirik
Published 2013-05-01

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis

by Marta Tesi, Marco Bugliani, Gianmarco Ferri, Mara Suleiman, Carmela De Luca, Emanuele Bosi, Matilde Masini, Vincenzo De Tata, Conny Gysemans, Francesco Cardarelli, Miriam Cnop, Decio L. Eizirik, Piero Marchetti, Lorella Marselli
Published 2021-02-01

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

by Maria Lytrivi, Kassem Ghaddar, Miguel Lopes, Victoria Rosengren, Anthony Piron, Xiaoyan Yi, Henrik Johansson, Janne Lehtiö, Mariana Igoillo-Esteve, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Henrik Ortsäter, Decio L. Eizirik, Miriam Cnop
Published 2020-08-01

Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa

by Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Narayana Murthy Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio L. Eizirik
Published 2018-08-01

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

by Gabriela Bomfim Ferreira, An-Sofie Vanherwegen, Guy Eelen, Ana Carolina Fierro Gutiérrez, Leentje Van Lommel, Kathleen Marchal, Lieve Verlinden, Annemieke Verstuyf, Tatiane Nogueira, Maria Georgiadou, Frans Schuit, Décio L. Eizirik, Conny Gysemans, Peter Carmeliet, Lut Overbergh, Chantal Mathieu
Published 2015-02-01

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.

by Mariana Igoillo-Esteve, Anne Genin, Nelle Lambert, Julie Désir, Isabelle Pirson, Baroj Abdulkarim, Nicolas Simonis, Anais Drielsma, Lorella Marselli, Piero Marchetti, Pierre Vanderhaeghen, Décio L Eizirik, Wim Wuyts, Cécile Julier, Ali J Chakera, Sian Ellard, Andrew T Hattersley, Marc Abramowicz, Miriam Cnop
Published 2013-10-01

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

by Décio L Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo-Esteve, Fernanda Ortis, Izortze Santin, Maikel L Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I McCarthy, Miriam Cnop
Published 2012-01-01

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 inductionResearch in context

by Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Published 2018-10-01

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

by Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lorenzo Pasquali, Décio L. Eizirik
Published 2020-05-01