Atrophy in the Thalamus But Not Cerebellum Is Specific for C9orf72 FTD and ALS Patients – An Atlas-Based Volumetric MRI Study

Atrophy in the Thalamus But Not Cerebellum Is Specific for C9orf72 FTD and ALS Patients – An Atlas-Based Volumetric MRI Study

Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyo...

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Main Authors: Sonja Schönecker, Christiane Neuhofer, Markus Otto, Albert Ludolph, Jan Kassubek, Bernhard Landwehrmeyer, Sarah Anderl-Straub, Elisa Semler, Janine Diehl-Schmid, Catharina Prix, Christian Vollmar, Juan Fortea, Deutsches FTLD-Konsortium, Hans-Jürgen Huppertz, Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Marianne Dieterich, Matthias L. Schroeter, Alexander E. Volk, Klaus Fließbach, Anja Schneider, Johannes Kornhuber, Manuel Maler, Johannes Prudlo, Holger Jahn, Tobias Boeckh-Behrens, Adrian Danek, Thomas Klopstock, Johannes Levin, Carola Roßmeier, Franziska Albrecht, Katharina Schümberg, Sandrine Bisenius
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
C9orf72
frontotemporal dementia
amyotrophic lateral sclerosis
atlas based volumetric MRI analysis
thalamus
cerebellum
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00045/full

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http://journal.frontiersin.org/article/10.3389/fnagi.2018.00045/full

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