Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.

Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.

INTRODUCTION: Recent studies have shown that histones, the chief protein component of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and act as major mediators of the death of an organism. This study was designed to elucidate the cellular...

Full description

Bibliographic Details
Main Authors: Mayumi Nakahara, Takashi Ito, Ko-ichi Kawahara, Mika Yamamoto, Tomoka Nagasato, Binita Shrestha, Shingo Yamada, Takahiro Miyauchi, Koji Higuchi, Toshihiro Takenaka, Tomotsugu Yasuda, Akira Matsunaga, Yasuyuki Kakihana, Teruto Hashiguchi, Yuichi Kanmura, Ikuro Maruyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3786915?pdf=render

Internet

http://europepmc.org/articles/PMC3786915?pdf=render

Similar Items