Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

Background: Accumulation of myeloid-derived suppressor cells (MDSCs) to tumors is related to cancer prognosis. We investigated the contribution of host stromal microsomal prostaglandin E synthase-1 (mPGES-1) to the accumulation of MDSCs in metastasized lungs of prostate cancer in mice. Material and...

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Bibliographic Details
Main Authors: Ryo Takahashi, Hideki Amano, Yoshiya Ito, Koji Eshima, Takefumi Satoh, Masatsugu Iwamura, Masaki Nakamura, Hidero Kitasato, Satoshi Uematsu, Joan Raouf, Per-Johan Jakobsson, Shizuo Akira, Masataka Majima
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MDSC
mPGES-1
Prostate cancer
Lung metastasis
SDF-1/CXCR4 axis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219352035

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http://www.sciencedirect.com/science/article/pii/S0753332219352035

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