Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling

Absence of Non-Canonical, Inhibitory MYD88 Splice Variants in B Cell Lymphomas Correlates With Sustained NF-κB Signaling

Gain-of-function mutations of the TLR adaptor and oncoprotein MyD88 drive B cell lymphomagenesis via sustained NF-κB activation. In myeloid cells, both short and sustained TLR activation and NF-κB activation lead to the induction of inhibitory MYD88 splice variants that restrain prolonged NF-κB acti...

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Bibliographic Details
Main Authors: Yamel Cardona Gloria, Stephan H. Bernhart, Sven Fillinger, Olaf-Oliver Wolz, Sabine Dickhöfer, Jakob Admard, Stephan Ossowski, Sven Nahnsen, Reiner Siebert, Alexander N. R. Weber
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
MYD88
B cell lymphoma
DLBCL - diffuse large B cell lymphoma
NF- kappa B
TLR - Toll-like receptor
alternative splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.616451/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.616451/full

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