M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.

The ectodomain of influenza A matrix protein 2 (M2e) is a candidate for a universal influenza A vaccine. We used recombinant Hepatitis B core antigen to produce virus-like particles presenting M2e (M2e-VLPs). We produced the VLPs with and without entrapped nucleic acids and compared their immunogeni...

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Bibliographic Details
Main Authors: Lorena Itatí Ibañez, Kenny Roose, Marina De Filette, Michael Schotsaert, Jessica De Sloovere, Stefan Roels, Charlotte Pollard, Bert Schepens, Johan Grooten, Walter Fiers, Xavier Saelens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3601086?pdf=render

Internet

http://europepmc.org/articles/PMC3601086?pdf=render

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