Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells

Molecular, Biological and Structural Features of VL CDR-1 Rb44 Peptide, Which Targets the Microtubule Network in Melanoma Cells

Microtubules are important drug targets in tumor cells, owing to their role in supporting and determining the cell shape, organelle movement and cell division. The complementarity-determining regions (CDRs) of immunoglobulins have been reported to be a source of anti-tumor peptide sequences, indepen...

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Bibliographic Details
Main Authors: Natalia Girola, Pedro T. Resende-Lara, Carlos R. Figueiredo, Mariana H. Massaoka, Ricardo A. Azevedo, Rodrigo L. O. R. Cunha, Luciano Polonelli, Luiz R. Travassos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
metastatic melanoma
microtubule
tubulin
peptide
complementarity-determining region
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00025/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00025/full

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