Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Summary: Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the metabolic consequences...

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Bibliographic Details
Main Authors: Mehmet G. Badur, Thangaselvam Muthusamy, Seth J. Parker, Shenghong Ma, Samuel K. McBrayer, Thekla Cordes, Jose H. Magana, Kun-Liang Guan, Christian M. Metallo
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315341

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http://www.sciencedirect.com/science/article/pii/S2211124718315341

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