KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs act as polycomb response elements (PREs) and are recognized by the polycomb silencing systems to regulate expression of genes involved in early development. How CGIs function mechanistically as nucleation sites fo...

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Bibliographic Details
Main Authors: Anca M Farcas, Neil P Blackledge, Ian Sudbery, Hannah K Long, Joanna F McGouran, Nathan R Rose, Sheena Lee, David Sims, Andrea Cerase, Thomas W Sheahan, Haruhiko Koseki, Neil Brockdorff, Chris P Ponting, Benedikt M Kessler, Robert J Klose
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2012-12-01
Series:eLife
Subjects:
CpG island
Chromatin
epigenetic
Transcription
Methylation
Demethylase
Online Access:https://elifesciences.org/articles/00205

Internet

https://elifesciences.org/articles/00205

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