Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

While studying transgenic mice that overexpress human wildtype alpha-synuclein (Thy1-ASO, ASO) for typical brain alpha-synucleinopathy and central nervous system neuropathology, we observed progressive functional changes in the gastrointestinal and other peripheral organs. A more systematic study re...

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Bibliographic Details
Main Authors: Penelope J. Hallett, Jesse R. McLean, Andrew Kartunen, J. William Langston, Ole Isacson
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Synucleinopathy
Parkinson's disease
Constipation
Gastrointestinal
Autonomic
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001386

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http://www.sciencedirect.com/science/article/pii/S0969996112001386

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