Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice

Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice

Fluorescent calcium (Ca2+) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sens...

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Bibliographic Details
Main Authors: Henry Lütcke, Masanori Murayama, Thomas Hahn, David J Margolis, Simone Astori, Stephan Meyer, Werner Göbel, Ying Yang, Wannan Tang, Sebastian Kügler, Rolf Sprengel, Takeharu Nagai, Atsushi Miyawaki, Matthew E Larkum, Fritjof Helmchen, Mazahir T Hasan
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-04-01
Series:Frontiers in Neural Circuits
Subjects:
Calcium
Neocortex
barrel cortex
two-photon microscopy
adeno-associated virus
yellow cameleon
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2010.00009/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2010.00009/full

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