Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment, patients develop resistance by mechanisms tha...

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Bibliographic Details
Main Authors: Carlos R. Figueiredo, Ricardo A. Azevedo, Sasha Mousdell, Pedro T. Resende-Lara, Lucy Ireland, Almudena Santos, Natalia Girola, Rodrigo L. O. R. Cunha, Michael C. Schmid, Luciano Polonelli, Luiz R. Travassos, Ainhoa Mielgo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
metastatic melanoma
macrophages
dendritic cells
immune response
peptide-based immunotherapy
macrophage migration inhibitory factor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01132/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01132/full

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