Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation

Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation

Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular mechanisms leading to β-cell failure as result of HNF4α mutation. In this study...

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Bibliographic Details
Main Authors: Luiza Ghila, Yngvild Bjørlykke, Thomas Aga Legøy, Heidrun Vethe, Kenichiro Furuyama, Simona Chera, Helge Ræder
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomedicines
Subjects:
miRNA
hiPSC
HNF4α
MODY1
insulin-producing cells
in-vitro differentiation
Online Access:https://www.mdpi.com/2227-9059/8/7/179

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https://www.mdpi.com/2227-9059/8/7/179

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