Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer's disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity in comparison to full-length Aβ, suggesting that these amyloid peptides may...

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Bibliographic Details
Main Authors: Jose S. Lopez-Noguerola, Nicolai M. E. Giessen, Maximilian Ueberück, Julius N. Meißner, Charlotte E. Pelgrim, Johnathan Adams, Oliver Wirths, Yvonne Bouter, Thomas A. Bayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
N-truncated Aβ
pyroglutamate Aβ
neuron loss
intraneuronal Aβ
behavior
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00064/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00064/full

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