A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

Background: Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral reservoir, but the low frequency of these cells makes this very challenging. Methods: We developed TILDA (Tat/rev Induced Limiting Dilutio...

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Bibliographic Details
Main Authors: Francesco Andrea Procopio, Rémi Fromentin, Deanna A. Kulpa, Jessica H. Brehm, Anne-Gaelle Bebin, Matthew C. Strain, Douglas D. Richman, Una O'Doherty, Sarah Palmer, Frederick M. Hecht, Rebecca Hoh, Richard J.O. Barnard, Michael D. Miller, Daria J. Hazuda, Steven G. Deeks, Rafick-Pierre Sékaly, Nicolas Chomont
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:EBioMedicine
Subjects:
HIV
Latency
Inducible virus
Reservoir
Multiply spliced RNA
Eradication
TILDA
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415300487

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http://www.sciencedirect.com/science/article/pii/S2352396415300487

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