Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2

Gab2 is a scaffolding protein, overexpressed in many types of cancers, that plays a key role in the formation of signaling complexes involved in cellular proliferation, migration, and differentiation. The interaction between Gab2 and the C-terminal SH3 domain of the protein Grb2 is crucial for the a...

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Bibliographic Details
Main Authors: Francesca Malagrinò, Antonio Coluccia, Marianna Bufano, Giuseppe La Regina, Michela Puxeddu, Angelo Toto, Lorenzo Visconti, Alessio Paone, Maria Chiara Magnifico, Francesca Troilo, Francesca Cutruzzolà, Romano Silvestri, Stefano Gianni
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
Gab2
SH3 domain
virtual screening
kinetics
cancer cell lines
Online Access:https://www.mdpi.com/2073-4409/9/11/2435

Internet

https://www.mdpi.com/2073-4409/9/11/2435

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