Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

DNA replication errors that persist as mismatch mutations make up the molecular fingerprint of mismatch repair (MMR)-deficient tumors and convey them with resistance to standard therapy. Using whole-genome and whole-exome sequencing, we here confirm an MMR-deficient mutation signature that is distin...

Full description

Bibliographic Details
Main Authors: Hui Zhao, Bernard Thienpont, Betül Tuba Yesilyurt, Matthieu Moisse, Joke Reumers, Lieve Coenegrachts, Xavier Sagaert, Stefanie Schrauwen, Dominiek Smeets, Gert Matthijs, Stein Aerts, Jan Cools, Alex Metcalf, Amanda Spurdle, ANECS, Frederic Amant, Diether Lambrechts
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
whole-genome sequencing
mismatch repair deficiency
mutation pattern
MSI
DNA double-strand break
DSB inducer
Online Access:https://elifesciences.org/articles/02725

Internet

https://elifesciences.org/articles/02725

Similar Items