Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks
DNA replication errors that persist as mismatch mutations make up the molecular fingerprint of mismatch repair (MMR)-deficient tumors and convey them with resistance to standard therapy. Using whole-genome and whole-exome sequencing, we here confirm an MMR-deficient mutation signature that is distin...
Main Authors: | Hui Zhao, Bernard Thienpont, Betül Tuba Yesilyurt, Matthieu Moisse, Joke Reumers, Lieve Coenegrachts, Xavier Sagaert, Stefanie Schrauwen, Dominiek Smeets, Gert Matthijs, Stein Aerts, Jan Cools, Alex Metcalf, Amanda Spurdle, ANECS, Frederic Amant, Diether Lambrechts |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/02725 |
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